Determination of the Effects of Eruca sativa Oil, Sodium Carbonate, Lavender Oil and Aloe vera Oil on Lipid Profile and Breast Tumour Markers in Breast Cancer-induced Doxorubicin Treated Female Albino Rats

Abstract

Background: Lavender oil, Eruca sativa oil and Aloe vera oil contain different types of fatty acids in addition to minerals, vitamins and other compounds which have anti-tumour action and antioxidant properties also it has cure properties against many other diseases. Sodium carbonate is alkaline material that affecting tissue PH and somewhat affecting on breast cancer through changing PH of the tissue making the medium not appropriate for breast cancer induction. Aim: Is studying the effect of Eruca sativa oil, Sodium carbonate, Lavender oil and Aloe vera oil on lipid profile, Tumor markers of breast cancer and thyroid hormones. Materials and Methods: Six groups of animals, five rats in each were used for this experiment and divided into negative control, positive control, sodium carbonate group, Eruca sativa oil group, lavender oil group and Aloe vera oil group. We induced cancer in all rats by MCF7 breast cancer cell line except negative control. Then all groups (Except positive and negative controls) were intraperitoneally (i.p.) injected with 2 mg /rat of adryadox (adryamycin chemotherapy), the remaining three groups except sodium carbonate group are supplemented with 1 ml. of the oil.  Then rats are sacrificed and blood is centrifuged to obtain serum and analysis of lipid profile and breast cancer tumour markers. Results: Eruca sativa oil and Aloe vera decrease cholesterol and triglycerides, where Eruca s. oil, Lavender oil and Aloe vera oil increase HDL more than sodium carbonate, Erucas. oil, Lavender oil and Aloe vera oil decrease LDL. Eruca s. oil decrease VLDL, sodium carbonate decreases alpha-fetoprotein and Ca15-3.  Conclusion and Recommendation: Based on the findings of this study, we recommend the use of lavender oil, Eruca sativa oil, Aloe vera oil and sodium carbonate administered at low doses as a helper in cure chemotherapy in treatment of breast cancer because it has useful effect in decreasing tumor markers and lipids and improve heart properties.