Overview of Scleroderma Renal Crisis - A Review
Mohammed Salah Hussein, Fozah sultan F. Alshammari, Rayan Jahz N. Almutihi, H. Alrougi Abdullah Fahad, Hussain Ali Busaleh, S. Altammami Sultan Saleh, Amal Mohsin Almaghribi Shiha, Suwaydi Essa Alsalami, Hussam Obaid Abdullah Al Harbi, Khadijah Nasr Aldeen M. Dhafer, Fatimah Essa Alhammaqi
Journal of Pharmaceutical Research International · pp. 334–340 · Published 1 Oct 2021
10.9734/jpri/2021/v33i45A32751Abstract
Scleroderma renal crisis is a life-threatening condition. It usually starts with a sudden onset of severe hypertension, followed by renal failure, hypertensive encephalopathy, congestive heart failure, and/or microangiopathic hemolytic anemia. Renal ischemia, hyperplasia of the juxtaglomerular apparatus, activation of the renin-angiotensin-aldosterone system (RAAS), and an increase in blood pressure are caused by decreased blood flow caused by structural changes in the blood vessels as well as renal vasospasm ("Raynaud's phenomenon"). This overview discusses the evaluation, diagnosis, and treatment of scleroderma renal crisis, emphasizing the importance of early detection of disease, strong correlation of corticosteroids intake and the disease incidence, and best approach of such cases.
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Suela Mumajesi, Saimir Seferi, Nereida Spahia · Cureus · 2025
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