Overview of Cellular Therapy: Reshaping the Wound in Diabetic Foot Ulcer

Abstract

Background: Diabetic Foot Ulcer (DFU) occurs due to a number of factors that compromises the peripheral neuropathy, mechanical changes in conformation of the bony architecture of the foot. Different types of cellular therapy and particularly Stem cells have been used by various medical groups around the world in treating a number of conditions. Stem cells can be generally derived from bone marrow, Placenta, Umbilical cord stem cells are found to have anti-inflammatory properties and immunomodulatory properties that can be beneficial in the process of angiogenesis, and reshape the wounds. Key Facts: Cells based treatment help to increase the re-epithelization in the foot ulcers. Stem cells have paracrine effects that improve angiogenesis, decrease inflammation, have anti-apoptotic and chemotactic signaling effects encourage beneficial extracellular matrix remodeling. Conclusion: Cellular therapy could support wound healing by stimulating the formation of new blood vessels, presence of a mixture of growth factors or up-regulating local growth factors that increase blood supply, re-growth the necrotic cells, and relieve lower limb ischemia.