Skip to content
Research Article Open access CC BY 4.0

Outcomes of Acute Kidney Injury Patients with and Without Cancer: A Single Center Study

Juwon Lee, Ye Na Kim, Ho Sik Shin

Journal of Advances in Medicine and Medical Research · pp. 255–262 · Published 17 Feb 2015

10.9734/BJMMR/2015/15899

Abstract

Background: Acute kidney injury (AKI) is a frequent complication in hospitalized patients. Incidence of AKI in hospitalized patients with cancer is increasing, but there have been few studies on AKI in patients with cancer. The purposes of this study were: 1. To evaluate and compare the characteristics and outcomes of cancer and non-cancer AKI patients; 2. To determine the impact of cancer diagnosis on hospital mortality of AKI patients; and 3. To compare outcome predictors between the two groups of AKI patients. Methods: We conducted a retrospective cohort study in a South Korean tertiary care hospital. A total of 2211 consecutive patients (without cancer 61.5%; with cancer 38.5%) were included over a 140-month period. Predictors of all-cause death were examined using the Kaplan-Meier method and the Cox proportional hazards model. Results: The main contributing factors of AKI were sepsis (31.1%) and ischemia (52.7%). AKI was multifactorial in 78% of patients with cancer and in 71% of patients without cancer. Hospital mortality rates were higher in patients with cancer (42.8%) than in patients without cancer (22.5%) (P = 0.014). In multivariate analyses, diabetes mellitus (DM) and cancer diagnosis were associated with hospital mortality. Cancer diagnosis was independently associated with mortality [odds ratio = 3.010 (95% confidence interval, 2.340-3.873), P = 0.001]. Kaplan-Meier analysis revealed that subjects with DM and cancer (n = 146) had lower survival rates than subjects with DM and without cancer (n = 687) (log rank test, P = 0.001). Conclusion: The presence of DM and cancer were independently associated with mortality in AKI patients both with and without cancer. Studies are warranted to determine whether proactive measures may limit AKI and improve outcomes.

Acute kidney injury cancer DM mortality

References (14)

  1. 1 Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients [DOI]
  2. 2 Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes [DOI]
  3. 3 Risk of radiocontrast nephropathy in patients with and without diabetes mellitus [DOI]
  4. 4 Improving Outcomes From Acute Kidney Injury: Report of an Initiative [DOI]
  5. 5 Incidence of acute kidney injury in cancer patients: A Danish population-based cohort study [DOI]
  6. 6 Prognosis of Critically Ill Patients With Cancer and Acute Renal Dysfunction [DOI]
  7. 7 Cancer and renal insufficiency results of the BIRMA study [DOI]
  8. 8 Trends in the Incidence of Acute Kidney Injury in Patients Hospitalized With Acute Myocardial Infarction [DOI]
  9. 9 Epidemiology of Acute Kidney Injury [DOI]
  10. 10 Development of a Clinical Research Agenda for Acute Kidney Injury Using an International, Interdisciplinary, Three-Step Modified Delphi Process [DOI]
  11. 11 Onconephrology [DOI]
  12. 12 Acute Kidney Injury in Critically Ill Patients with Cancer [DOI]
  13. 13 Outcomes of cancer and non-cancer patients with acute kidney injury and need of renal replacement therapy admitted to general intensive care units [DOI]
  14. 14 Small increases in serum creatinine are associated with prolonged ICU stay and increased hospital mortality in critically ill patients with cancer [DOI]

Cited by 4

A nomogram for predicting the mortality of patients with type 2 diabetes mellitus complicated with acute kidney injury in the intensive care unit

Shi-Zhen Liu, Chuang-Ye Qiu, Xing-Ai Li · BMC Anesthesiology · 2023

Risk of acute kidney injury in cancer patients after iodinated contrast medium administration and prophylactic strategies: Summary from the most recent guidelines

Pirovano Marta, Minei Silvia, Re Sartò Giulia Vanessa · Journal of Onco-Nephrology · 2021

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

C. Thongprayoon, P. Hansrivijit, K. Kovvuru · Journal of Clinical Medicine · 2020

Acute kidney injury from contrast-enhanced CT procedures in patients with cancer: white paper to highlight its clinical relevance and discuss applicable preventive strategies

L. Cosmai, C. Porta, C. Privitera · ESMO Open · 2020

Related research

Article metrics

Real usage data collected on this platform.

47

Page views

0

PDF downloads

9

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.