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Research Article Open access CC BY 3.0

Oropharyngeal Candidiasis in HIV Suspected Patients Attending State Hospital Ijebu-Ode Ogun State Nigeria

O. M. Lakunle, A. Oluwadun, C. O. Adegoke, S. T. Ogunbanwo, H. I. Effedua

Microbiology Research Journal International · pp. 1451–1462 · Published 6 Aug 2014

10.9734/BMRJ/2014/9150

Abstract

Aims: To determine the effect of CD4 count (a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages and dendritic cells) on the Candida species associated with Oropharyngeal candidiasis among HIV suspected patients. Place and Duration of the Study: State Hospital Ijebu Ode Ogun State Nigeria between February 2010 to August 2011. Methodology: Outpatients attending State Hospital Ijebu Ode were screened for HIV infection using Determine kits, Stat-pak kits and Unigold test kits. Western blot was used to confirm HIV infection and to determine the predominance of HIV specific glycoproteins in HIV seropositive patients. A total of 350 samples of sputum and blood from the HIV seropositive individuals while 300 samples from the HIV seronegative individuals. Sputum samples were cultured on sabouraud dextrose agar, and the isolates were Gram stained while the yeast-like fungi were subjected to germ tube test. CD4 count in blood samples was determined using flow cytometry. Results: HIV prevalence in females was 70.6% and in males was 29.4%. From three hundred and fifty patients suspected as HIV positive, seventy three had oral candidiasis (20.9%) while 277 (79.1%) were candidiasis negative. Higher oral candidiasis occurred in females (22.7%) than in males (16.5%). Candida alblicans was found to have higher occurrence of 86% among other Candida species. There is no significant association between the occurrence of oral candidiasis and the age of HIV subjects. There was higher occurrence of cases of immune depression (<350 CD4 count) in HIV seropositive (56.3%) than in HIV seronegative (0%) subjects. Candida infections occur when CD4 count was 200-500 cell/µl and usually represent the first indication of immune suppression. Decrease in CD4 count led to increase in occurrence of Candida species. The lowest number of Candida species was recorded when CD4 count was above 300 and Candida alblicans is the most predominant species isolated in this study. Conclusion: The result of this study shows that HIV infection led to decrease in CD4 count which in turn promotes candidiasis.

HIV-Subjects oropharyngeal candidiasis Diagnostic kit

References (34)

  1. 1 Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men [DOI]
  2. 2 An Outbreak of Community-AcquiredPneumocystis cariniiPneumonia [DOI]
  3. 3 Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome [DOI]
  4. 4 Trends in Mortality Due to Invasive Mycotic Diseases in the United States, 1980–1997 [DOI]
  5. 5 Fungal Infection - Diagnosis and Management
  6. 6 Incidence of candidaemia and relationship with fluconazole use in an intensive care unit [DOI]
  7. 7 Role of Hyphal Formation in Interactions of Candida albicans with Endothelial Cells [DOI]
  8. 8 Assessing risk factors for systemic fungal infections [DOI]
  9. 9 Oral manifestations in 101 Cambodian patients with HIV infection and AIDS [DOI]
  10. 10 Fungal infections in HIV-infected patients [DOI]
  11. 11 OralCandidaIsolates Colonizing or Infecting Human Immunodeficiency Virus-Infected and Healthy Persons in Mexico [DOI]
  12. 12 EPIDEMIOLOGY OF INVASIVE FUNGAL INFECTIONS IN THE MEDITERRANEAN AREA [DOI]
  13. 13 Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p [DOI]
  14. 14 Opportunistic diseases reported in AIDS patients: frequencies, associations, and trends.
  15. 15 Evaluation of Phenotypic Markers for Selection and Identification of Candida dubliniensis [DOI]
  16. 16 Retrospective Identification and Characterization of Candida dubliniensis Isolates among Candida albicans Clinical Laboratory Isolates from Human Immunodeficiency Virus (HIV)-Infected and Non-HIV-Infected Individuals [DOI]
  17. 17 Culture and Identification of Candida Albicans from Vaginal Ulcer and Separation of Enolase on SDS-PAGE [DOI]
  18. 18 Oral manifestations in HIV‐positive adults from Northern Thailand [DOI]
  19. 19 Women as dental patients: are there any gender differences?
  20. 20 Comorbidities among HIV-infected injection drug users in Chennai, India.
  21. 21 Association of asymptomatic oral candidal carriage, oral candidiasis and CD4+ lymphocyte count in HIV‐positive patients in China [DOI]
  22. 22 Oral manifestations in 100 Zimbabwean HIV/AIDS patients referred to a specialist centre.
  23. 23 Changing Epidemiology of Classical and Emerging Human Fungal Infections: A Review
  24. 24 Progression to AIDS in HIV-infected homosexual and bisexual men with hairy leukoplakia and oral candidiasis [DOI]
  25. 25 Oral manifestations of HIV in a southeast USA population [DOI]
  26. 26 Human Immunodeficiency Virus—Related Oral Manifestations and Gender [DOI]
  27. 27 The Role ofCandida dubliniensisin Oral Candidiasis in Human Immunodeficiency Virus-Infected Individuals [DOI]
  28. 28 Oral manifestation of HIV/AIDS in a Kenyan provincial hospital [DOI]
  29. 29 Knowledge, attitude, the perceived risks of infection and sources of information about HIV/AIDS among pregnant women in an urban population of Delhi.
  30. 30 Fungemia due to Candida guilliermondii in a pediatric and adult population during a 12-year period [DOI]
  31. 31 Pathogenic fungal isolates in sputum of HIV positive patients [DOI]
  32. 32 Differential Resistance to Oxidants and Production of Hydrolytic Enzymes in Candida albicans [DOI]
  33. 33 HIV-related oral diseases in Benin City, Nigeria.
  34. 34 Susceptibility profile of yeast-like organisms isolated from HIV/AIDS patients; using NCCLs macrodiltion method compared with agar diffusion technique. [DOI]

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