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Research Article Open access CC BY 3.0

Oral Adverse Reaction to Cefuroxime Axetil

V. Vucicevic Boras, V. Brailo, D. Vidovic Juras, S. Ljubojevic Hadzavdic, D. Gabric Panduric

Annual Research & Review in Biology · pp. 2471–2475 · Published 17 Apr 2014

10.9734/ARRB/2014/10103

Abstract

A 62 year old female patient was referred to the Department of oral medicine due to the severe oral reaction two days after she started to use cefuroxime axetil. Buccal and sublingual mucosa was very inflamed and covered with thick pseudomembranes. Patient was otherwise healthy and did not take any medication. She was advised to stop the suspected drug intake immediately and was given intramuscular methylprednisolone injection (40mg, i.e. 1mg/kg) as well as chlorhexetidine mouthwash with local anaesthetic (Xylocaine) to be used at home three times a day. After seven days the lesions healed completely. Two months after the adverse drug side effect, allergic tests were performed. In vitro tests (indirect degranulation of basophile granulocytes and blast transformation of lymphocytes) as well asepicutaneous test were negative to cefuroxime axetil.

Cefuroxime axetil oral adverse reaction.

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