Optimization of Process Parameters for Improved Production of Bioactive Metabolites by Streptomyces tritolerans DAS 165T
Usha Kiranmayi Mangamuri, Vijayalakshmi Muvva, Sudhakar Poda, Dayanand Agasar
Microbiology Research Journal International · pp. 428–442 · Published 12 Jan 2014
10.9734/BMRJ/2014/7086Abstract
Aims: To optimize the process parameters for enhanced production of bioactive metabolites by Streptomyces tritolerans DAS 165T. Place and Duration of Study: Department of Botany and Microbiology, April 2012 to August 2012. Methodology: Agar well diffusion assay was employed to study the effect of environmental parameters such as incubation period, pH, temperature and salt concentration and influence of various nutrients such as carbon and nitrogen sources and minerals on the bioactive metabolite production by Streptomyces tritolerans DAS 165T. Results: The production of antimicrobial metabolite was high when the strain was cultured for six days at 35ºC in medium (pH 7.5) with sucrose at the concentration of 2% (carbon source), soya peptone at the concentration of 1% (nitrogen source) and sodium chloride at the concentration of 5%. Conclusion: This is the first report on the optimization of bioactive metabolite production by Streptomyces tritolerans DAS 165T. As the strain exhibited potent antimicrobial activity, it may be explored for biotechnological purposes.
References (28)
- 1 Bioactive Microbial Metabolites [DOI]
- 2 Microbiology Laboratory Manual [DOI]
- 3 ECOLOGY OF ACTINOMYCETES [DOI]
- 4 A Kinetic Model for Substrate and Energy Consumption of Microbial Growth under Substrate‐Sufficient Conditions [DOI]
- 5 Evaluation of antibacterial properties of some medicinal plants used in Iran [DOI]
- 6 Studies on a new marine streptomycete BT-408 producing polyketide antibiotic SBR-22 effective against methicillin resistant Staphylococcus aureus [DOI]
- 7 The evolution of development inStreptomycesanalysed by genome comparisons [DOI]
- 8 Influence of nutrition and culturing conditions for optimum growth and antimicrobial metabolite production by Streptomyces sp. 201 [DOI]
- 9 Fungicidal activity of marine actinomycetes against phytopathogenic fungi
- 10 Physiology and nutritional aspects of actinomycetes: an overview [DOI]
- 11 Optimal Conditions for Antimicrobial Metabolites Production from a NewStreptomycessp. RUPA-08PR Isolated from Bangladeshi Soil [DOI]
- 12 Antimicrobial properties of actinomycetes from the soil of Himalaya [DOI]
- 13 Optimization of the cultivation medium for natamycin production byStreptomyces natalensis [DOI]
- 14 Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes [DOI]
- 15 The role of pH in the ‘glucose effect’ on prodigiosin production by non‐proliferating cells of Serratia marcescens [DOI]
- 16 Screening of Indian coastal plant extracts for larvicidal activity of Culex quinquefasciatus [DOI]
- 17 Effects of some environmental conditions on biomass and antimicrobial metabolite production by Streptomyces sp., KGG32.
- 18 Effects of glucose, growth temperature, and pH on listeriolysin O production in Listeria monocytogenes [DOI]
- 19 ANTIBIOTIC PRODUCTION BY STREPTOMYCES HYGROSCOPICUS D1.5: CULTURAL EFFECT [DOI]
- 20 Streptomyces axinellae sp. nov., isolated from the Mediterranean sponge Axinella polypoides (Porifera) [DOI]
- 21 A study of antifungal antibiotic production by Thermomonospora sp MTCC 3340 using full factorial design [DOI]
- 22 Screening of Variables Influencing the Clavulanic Acid Production by Streptomyces DAUFPE 3060 Strain [DOI]
- 23 Influence of cultural conditions for improved production of bioactive metabolites by Streptomyces cheonanensis VUK-A isolated from coringa mangrove ecosystem
- 24 Optimisation of cultural conditions for antifungal antibiotic accumulation by Streptomyces rochei G164.
- 25 Streptomyces tritolerans sp. nov., a novel actinomycete isolated from soil in Karnataka, India [DOI]
- 26 Studies on the Production of Actinomycin by Nocardioides luteus, a Novel Source
- 27 Optimization of Conditions and in Vitro Antibacterial Activity of Secondary Metabolite Isolated from Streptomyces sp. MNK7
- 28 Alkaliphilic Soil Actinomycetes [DOI]
Cited by 14
Minakshi Sinha, Anuradha Tyagi, Shaurya Prakash · Microorganisms · 2026
Chiranjeevi Chetapalli, Nagaraju Kumbha, Mary Swapna Mogili · Brazilian Journal of Microbiology · 2026
F. Al-Asady, D. A. Al-Saray, Alaa H. Al-Charrakh · Medical Journal of Babylon · 2025
Y. Lestari, Lia Aseptin Murdini, D. Solihin · Hayati Journal of Biosciences · 2018
S. Satapathy, S. Mohapatra · 2017
H. Harikrishnan, V. Shanmugaiah, K. Nithya · Journal of Basic Microbiology · 2016
A. Aliero, A. Adam, Ibrahim Ntulume · 2018
Idris Adamu Matinja · 2016
Aruna, S. Rajan · 2015
R. Alnahdi · 2014
Showing 11 of 14 known citations — external sources report more than can currently be individually listed.
Related research
- Adhesion, Autoaggregation and Hydrophobicity of Six Lactobacillus Strains — shares topic coverage
- Antimicrobial Profiling of Selected Medicinal Plants from West Pokot, Kenya: Plant Parts and Concentration-Specific Effects — shares topic coverage
- Phytochemical Screening, Chemical Composition and Antimicrobial Activity of Cinnamon verum Bark — shares topic coverage
- Green Tamarind Extract Catalyzed Synthesis of 4-Amino-1,2,4-Triazole Derivatives and Their In-vitro Antimicrobial Activity — shares topic coverage
- Synthesis, Characterization, Spectral Studies and Antimicrobial Study on Mixed Ligand Complexes of Chloro-arsenic(III) Derived from β-Ketiminates & Piperidine Dithiocarbamate Ligand Moity — shares topic coverage
Article metrics
Real usage data collected on this platform.
94
Page views
0
PDF downloads
28
Outbound clicks
14
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.