Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study
Mohammad Muqtader Ahmed, Farhat Fatima, Abdul Bari Mohammed
Journal of Pharmaceutical Research International · pp. 29–36 · Published 20 Oct 2020
10.9734/jpri/2020/v32i2530821Abstract
The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers. Methods: Nine formulations developed by hot-melt method using olive oil, sorbitan monostearate (SMS) and FLZ. Prepared formulations characterized for macro evaluations, pH, spreadibility, viscosity, gel-sol transition, in-vitro diffusion study. Further optimized formulation evaluated for ex-vivo percutaneous permeation, in-vitro antifungal studies and stability studies by similarity index. Results: The results of evaluated parameters ensure the stability and effectiveness of the prepared olive oil based organogels. In-vitro diffusion studied reflects decrease in drug release with increase in surfactant concentration due to increase in viscosity. Moreover, ex-vivo permeation studies revealed that the permeation of FLZ was enhanced for optimized formulations (F6) as compared to the marketed gel formulation. Further, the optimized formulation exhibits the broad zone of inhibition against fungal strains in comparison to control and marketed product during in-vitro antifungal study. Conclusion: The olive oil based organogels formulation shown the enhanced permeation of FLZ from organogel network structure with good antifungal activity as compared to the marketed formulation. Henceforth, the FLZ organogel formulations could be used topically for the effective treatment of fungal infection.
Cited by 22
Dipanjana Ash, Sankhadip Bose, Biswajit Basu · Biomedical Materials & Devices · 2025
Mohammed MUQTADER AHMED-Farhat FATIMA · Journal of Research in Pharmacy · 2021
Mohammed Muqtader Ahmed, Farhat Fatima, Md. Khalid Anwer · Saudi Pharmaceutical Journal · 2021
Sultan Alshehri, Syed Sarim Imam · Drug Delivery · 2021
Gavin P. Andrews, Thomas Laverty, David S. Jones · Polymers · 2024
Amer S. Alali, Mohammed Muqtader Ahmed, Farhat Fatima · Journal of Applied Polymer Science · 2024
Aftab Alam, Ahmed I. Foudah, Mohammad Ayman Salkini · Gels · 2022
Farhat Fatima, Mohammed F. Aldawsari, Mohammed Muqtader Ahmed · Pharmaceutics · 2021
Mohd Nazam Ansari, Gamal A. Soliman, Najeeb Ur Rehman · Gels · 2022
Showing 9 of 22 known citations — external sources report more than can currently be individually listed.
Related research
- Radical Scavenging Capacity and Efficacy of Myristica fragrans (Nutmeg) Metabolites on Cladosporum herbarum of Food Origin — shares topic coverage
- Species Distribution and Drug Susceptibility of Candida Isolates from Various Clinical Specimens at a Tertiary Care Hospital in Kashmir — shares topic coverage
- Virulence Markers and Antifungal Susceptibility Profile of Candida glabrata: An Emerging Pathogen — shares topic coverage
- A Hospital-based Study on the Detection of Fluconazole-resistant Candida albicans from Women with Vulvovaginal Candidiasis in Port Harcourt — shares topic coverage
- In vitro Effect of the Association of Therapeutic Ultrasound to Fluconazole on the Growth Inhibition of Candida albicans — shares topic coverage
Article metrics
Real usage data collected on this platform.
5
Page views
0
PDF downloads
0
Outbound clicks
22
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.