olf413 Gene Controls Taste Recognition, Preference and Feeding Activity in Drosophila melanogaster
Ravindrakumar Ramya, Baragur Venkatanarayanasetty Shyamala
Annual Research & Review in Biology · pp. 24–31 · Published 27 Jun 2023
10.9734/arrb/2023/v38i530585Abstract
Recognition and responsiveness to food taste becomes a crucial event in foraging and feeding behaviour of an organism. Adjusting the feeding behaviour through a sophisticated and robust taste system is critical to fulfil their nutritional needs and facilitate its survival in environment. Palatability of food sources depends on the sensory and motor cues provided by the brain, in co-ordination with the other body systems to enable decisive feeding. Drosophila melanogaster is an apt model organism to decipher these behavioural paradigms. Octopamine a neurotransmitter, is required in regulation of feeding behavioural responses. olf413, a paralogue of T\(\beta\)H, is a gene predicted for its involvement in octopamine biosynthesis. The biological function of this gene is yet to be unravelled. Here we propose this gene function in taste recognition, food preference and feeding activity. We test the olf413 loss of function mutants for food preference between two fruit extracts using CAFE and horizontal box methods. In our study we have used olf413 gene disruption strain, olf413MI02014 homozygous and in transheterozygous condition with another allele isolated in our lab, olf413SG1.1. The results show that olf413 mutants display a severe phenotype in feeding behaviour and there is an allele specific phenotypic distinction between the two strains. Thus implying that olf413 gene function is required for taste recognition, starvation driven initiation and execution of feeding behaviour of the flies.
References (8)
- 1 InterPro in 2022 [DOI]
- 2 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium [DOI]
- 3 An integrative approach to ortholog prediction for disease-focused and other functional studies [DOI]
- 4 Genetic dissection of monoamine neurotransmitter synthesis in Drosophila [DOI]
- 5 Octopamine in invertebrates and vertebrates. A review [DOI]
- 6 Induction of host preference in Drosophila melanogaster [DOI]
- 7 Local and Seasonal Variations in Relative Frequencies of Species of Drosophila in Brazil [DOI]
- 8 Octopamine and Tyramine Contribute Separately to the Counter-Regulatory Response to Sugar Deficit in Drosophila [DOI]
Cited by 2
Ravindrakumar Ramya, Chikkate Ramakrishnappa Venkatesh, Baragur Venkatanarayanasetty Shyamala · BMC Research Notes · 2024
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Related research
- Reproductive and Oxidative Stress Toxicity of Dolutegravir-Based Combination Antiretroviral Therapy in Drosophila melanogaster — shares topic coverage
- EFVb-HAART Increases Mortality, Locomotor Deficits and Reduces Reproductive Capacity in Drosophila melanogaster — shares topic coverage
- The Climbing Performance, Neuromuscular Transmitter (ACHE) Activity, Reproductive Performance and Survival of Drosophila melanogaster Fed Diet with Mangifera indica Cold Aqueous Leaf Extract — shares topic coverage
- Anticonvulsant Activity of Elaesis guineensis (Jacq) Oil in Pentylenetetrazol-Induced Seizure in Drosophila melanogaster — shares topic coverage
- Phytochemical Constituents and Toxicity of the Ethanol Extract of Ricinus communis (L.) in Drosophila melanogaster — shares topic coverage
Article metrics
Real usage data collected on this platform.
8
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.