Spermatogenic Alterations Induced by Organophosporus Compounds Profenofos, Chlorpyrifos and Synthetic Pyrethroid Lambada-cyhalothrin in Mice

Abstract

Background: Fertility is declining in many countries and there has been substantial interest in the potential adverse effects of exposure to environmental hazardous chemicals, including pesticides on male reproduction, and it was evident that using pesticides play as the major reasons for sperm decline besides tested pesticides are used widely recently, that is why it was very important the investigate their draw back in fertilization. The objective of the present study focuses on the spermiotoxicity of some pesticides such as profenofos, chlorpyrifos, and lambda-cyhalothrin on male albino mice. Study Design: To assess the effect of tested pesticides on sperm morphology of male albino mice treated for 30, 60 and 90 consecutive days with different doses of pesticides (1/10, 1/40 and ADI LD50). Place and Duration of Study: Institute of animal health, Ministry of Agriculture, Egypt, between May 2011 and March 2012. Results: Data suggest a potential association between exposures to tested pesticides and decreased sperm quality and increased teratospermic (abnormal sperm morphology). Further support for testicular toxicity comes from studies in laboratory albino mice that showed associations between exposure tested pesticides and sperm shape abnormalities, as well as dose-response relationships between exposure and a decline in epididymal sperm count and motility and increased abnormal sperm. Conclusion: Tested pesticides can cause male reproductive system abnormalities that include reduced sperm production. It is also possible that the genetic information of the sperm may potentially be altered prior to fertilization.