Association of Apolipoprotein A Gene Polymorphism with Uncomplicated Plasmodium falciparum Malaria in Elfasher City, North Darfur, Sudan

Abstract

Aims: This study aimed to investigate the lipids profile, APOA genotype with malaria infection. It was hypothesized that the malaria parasite uses cholesterol and phospholipids from its host, resulting in a decrease in serum HDL. Study Design: A cross-sectional hospital -based study.  Place and Duration of Study: The study was conducted during the transmission season between July to November 2020 in different hospitals and centers in Elfasher city. Methodology: We included (39 men and 64 female), 57.3% were adults and 42.7% were children, plasmodium falciparum infection, with clinical symptoms and signs of uncomplicated malaria. Parasites density, lipids profile and APOA genotyping were assayed. Results: The mean level of CHOL and TG was 134.7 mg/dl and 73.0 mg/dl, respectively, and the average levels of LDL and HDL are 56.6 mg/dl and 56.2 mg/dl, respectively. The G/G genotypes of APOA were identified in 94.2% of the patients compared to other APOA genotypes. The overall allele frequency for the G allele was 96.0%, and the T allele was 3.9% using the Hardy-Weinberg distribution. Conclusion: In conclusions, the lipids profile and APOA genotype were not associated with uncomplicated malaria.