Novel and Investigational Drugs in Depression
Desiree N. Shapiro, Stephen M. Stahl
International Neuropsychiatric Disease Journal · pp. 328–347 · Published 17 Jul 2014
10.9734/INDJ/2014/11590Abstract
Major depressive disorder is a serious medical illness associated with significant burden. Our current treatments for depression are limited, which has motivated researchers to explore novel targets. This article will highlight new psychopharmacological agents and investigational directions which may show promise in achieving better outcomes and symptom relief for those suffering from depression. This review will address key categories of novel therapeutic targets for depression. The newer and investigational agents involving monoaminergic transmission will be discussed, followed by those with glutamatergic, opioid, anticholinergic, and miscellaneous mechanisms. As the field continues to learn more about the pathophysiology of depression, there will be an emergence of additional innovative targets and investigational mechanisms, along with an improvement in our treatment outcomes.
Cited by 1
H. Javelot · Annales Pharmaceutiques Françaises · 2016
Related research
- Prevalence and Correlates of Major Depressive Disorder among Human Immunodeficiency Virus Infected Adults in Sub-Saharan Africa: A Systematic Review and Meta-analysis — shares topic coverage
- Plant Medicine Healing! Discovering the Roots of Psychedelic-Assisted Therapy in Mental Health — shares topic coverage
- Association of Major Depression with Serum Prolidase Activity and Oxidative Stress — shares topic coverage
- Determining the Impact of Borderline Personality Disorder in the Treatment Outcome of Depression — shares topic coverage
- Escitalopram Usage Pattern in India: A Knowledge, Attitude and Practice Survey among Indian Psychiatrists — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.