Skip to content
Research Article Open access CC BY 4.0

Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)

Michael J. Adjabui, Nathaniel K. Howard, Albert Luguterah

Asian Research Journal of Mathematics · pp. 1–12 · Published 21 Sep 2017

10.9734/ARJOM/2017/36377

Abstract

In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose.

Maximum safe dose partitioning principle distribution-free endpoint familywise error rate confidence set.

References (14)

  1. 1 Nonparametric Statistical Methods [DOI]
  2. 2 nparcomp : An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals [DOI]
  3. 3 Mutagens in contaminated soil: a review [DOI]
  4. 4 The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity [DOI]
  5. 5 The mutagenic hazards of settled house dust: a review [DOI]
  6. 6 A review of the mutagenicity and rodent carcinogenicity of ambient air [DOI]
  7. 7 The Detection of Chemical Mutagens with Enteric Bacteria [DOI]
  8. 8 Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors [DOI]
  9. 9 Stepwise Confidence Intervals without Multiplicity Adjustment for Dose—Response and Toxicity Studies [DOI]
  10. 10 On Confidence Sets in Multiple Comparisons [DOI]
  11. 11 Detection of Mutagenic Activity in Cigarette Smoke Condensates [DOI]
  12. 12 Finding the Maximum Safe Dose Level for Heteroscedastic Data [DOI]
  13. 13 IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH [DOI]
  14. 14 Identifying effective and/or safe doses by stepwise confidence intervals for ratios [DOI]

Cited by 3

Identification of Maximum Safe Dose Based on Ratio of Normally Distributed Data under Heteroscedasticity

Emmanuel D. Kpeglo, Michael J. Adjabui, Jakperik Dioggban · Journal of Mathematics Research · 2022

Biostatistical Assessment of Mutagenicity Studies: A Stepwise Confidence Procedure

Michael J. Adjabui, Nathaniel K. Howard, Mathias Akamba · Journal of Probability and Statistics · 2019

Showing 2 of 3 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

14

Page views

0

PDF downloads

0

Outbound clicks

3

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.