Non-alcoholic Fatty Liver Disease and Cholesterol: The Lesser-known Links

Abstract

Non Alcoholic Fatty Liver Disease refers to a group of hepatic histological abnormalities that ranges from noninflammatory intra-cellular lipid collection to NASH develop, fibrosis, or hepato-cellular carcinoma, which results from a mismatch between lipid supply and lipid clearance, is a characteristic of Non Alcoholic Fatty Liver Disease. Recent buildup aetiology. Hepatic FC build up in Non Alcoholic Fatty Liver Disease  is caused by changes in intracellular cholesterol transport as well as a poorly balanced cellular cholesterol equilibrium characterized by an increased, and amplification of routes. With the induction of intra-cellular signalling pathway in stellate cells, Kupffer cells, including hepatocyte, FC build up causes liver damage. Inflammation and fibrogenesis are aided by the activation of Kupffer cells and stellate cells.. These episodes feed a never-ending cycle, which helps in forming steatosis while also promoting liver cells mortality, and hepatic injury, that can lead to disease progression. In this review, we highlight what we know about NAFLD's dysfunctional cholesterol homeostasis and look at the liver pathophysiologies and how they contribute to the disease's continuous liver injury. This knowledge's treatment implications are also highlighted. Inflammation and fibrogenesis are aided by the activation of KCs and HSCs. Furthermore, FC buildup in liver mitochondria causes mitochondrial malfunction, which leads to an increase in reactive oxygen species generation, as well as the unsettled response of proteins in the ER (endoplasmic reticulum), which leads to endoplasmic reticulum death.