Nilotinib-Induced Thromboembolic Events: A Case Study
Zahra Kmira, Ben Yahya Noura, Guermazi Monia, Fathallah Neila, Atig Amira, Chembah Wafa, Thabet Maissa, Zaier Monia, Ben Youssef Yosra, Haifa Regaieg, Khelif Abderrahim
Journal of Advances in Biology & Biotechnology · pp. 596–602 · Published 23 Jan 2025
10.9734/jabb/2025/v28i11912Abstract
Nilotinib has significantly improved the treatment of chronic myeloid leukemia (CML) by offering enhanced efficacy and tolerability. However, studies have revealed a concerning link between nilotinib and an increased risk of thromboembolic events, even compared to other tyrosine kinase inhibitors (TKIs). This case report presents a forty-four-year-old male with CML treated with nilotinib, who developed dyslipidemia and multiple arterial occlusive events, including renal thrombosis and carotid artery atheroma. The potential mechanisms underlying nilotinib-induced thromboembolic events are endothelial cell dysfunction, altered lipid metabolism, and pro-inflammatory and prothrombotic effects. Identifying preexisting cardiovascular risks and implementing proactive measures may aid in reducing the occurrence of thromboembolic events in high-risk patients treated with nilotinib.
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