Neuroprotective and Free Radicals Scavenging Potentials of Some Common Leafy Vegetables Consumed in South - Eastern Nigeria
C. S. Alisi, E. S. Asiwe, A. A. Emejulu, A. C. Ene, R. N. Nwoguikpe
Annual Research & Review in Biology · pp. 3345–3358 · Published 13 Jun 2014
10.9734/ARRB/2014/9666Abstract
Antioxidant potential, lipid peroxidation inhibition ability in brain homogenate and total phenolic and flavonoid contents of ethanol extracts of some leafy vegetables (Vernonia amygdalina, Gongronema latifolium and Ocimum gratissimum) consumed in south-eastern Nigeria were determined. The antioxidant and neuroprotective potentials of the ethanol extracts were assessed by 2, 2-diphenyl-1-picrylhydrazil (DPPH) assay and through determination of thiobarbituric acid (TBA) reactive substances in brain homogenates. Total phenolic and flavonoid contents were quantitatively determined in the extracts spectrophotometrically. Results obtained from the present study showed that G. latifolium and V. amygdalina extracts were effective against hydrogen peroxide-induced lipid peroxidation with threshold inhibitory concentrations (IC50) values of 357.36±15.6µg/ml and 629.5±22.72µg/ml respectively while O. gratissimum achieved only 20% inhibition (IC20) at 785.73±40.23µg/ml. In the DPPH free radical scavenging assay, 50% of DPPH radicals were scavenged at181.5(µg/ml), 153.33(µg/ml), and 189.67(µg/ml) of V. amygdalina, G. latifolium and O. gratissimum extracts concentrations respectively. Free radical scavenging ability of the extracts was in the order G. Latifolium >V. Amygdalina > O. gratissimum. Total phenolic content was 432.79±42.2mg/100g,274.1±37.3mg/100g, and 490.49±58.1mg/100g catechin equivalent, while flavonoid content was 843.09±21.6 mg/100g, 746.34±13.7mg/100g and 1160.98±24.5mg/100g catechin equivalent in V. amygdalina, G. latifoliumand O. gratissimum respectively. The inhibition of lipid peroxidation and DPPH radical scavenging followed a logistic dose response pattern.These results indicatethat these vegetables possess neuro-protective potentials and free radical scavenging ability. The present data scientifically corroborate with the consumption of these plants as an exogenous sources of antioxidants that could improve nutrition and boost antioxidant defense.
References (46)
- 1 An Algorithm for Least-Squares Estimation of Nonlinear Parameters [DOI]
- 2 Identification of human brain tumour initiating cells [DOI]
- 3 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes [DOI]
- 4 Kinetics and Mechanisms of Antioxidant Activity using the DPPH.Free Radical Method [DOI]
- 5 Antioxidant Activity of a Flavonoid-Rich Extract of Hypericum perforatum L . in Vitro [DOI]
- 6 Energetic basis of brain activity: implications for neuroimaging [DOI]
- 7 BIOFLAVONOIDS CLASSIFICATION, PHARMACOLOGICAL, BIOCHEMICAL EFFECTS AND THERAPEUTIC POTENTIAL
- 8 Demyelination: The Role of Reactive Oxygen and Nitrogen Species [DOI]
- 9 Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.) [DOI]
- 10 Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology [DOI]
- 11 Phytochemical constituent and antioxidant activity of extract from the leaves of Ocimum gratissimum [DOI]
- 12 Effect of blanching on the antioxidant properties of some tropical green leafy vegetables [DOI]
- 13 In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo [DOI]
- 14 Hot pepper (Capsicum annuum, Tepin and Capsicum chinese, Habanero) prevents Fe2+-induced lipid peroxidation in brain – in vitro [DOI]
- 15 Scavenging of reactive-oxygen species and DPPH free radicals by extracts of borage and evening primrose meals [DOI]
- 16 Flavonoids from Vernonia amygdalina and their antioxidant activities [DOI]
- 17 Antioxidant activity of Paraguayan plant extracts [DOI]
- 18 Nutritional potentials of some tropical vegetable leaf meals: chemical characterization and functional properties
- 19 Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets [DOI]
- 20 Factors influencing antioxidant activities and total phenolic content of guava leaf extract [DOI]
- 21 Vernonia amygdalina, an ethnoveterinary and ethnomedical used green vegetable with multiple bio-activities. [DOI]
- 22 Antioxidant activity of basil.
- 23 Effect of Naturally Occurring Flavonoids on Lipid Peroxidation and Membrane Permeability Transition in Mitochondria [DOI]
- 24 Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis [DOI]
- 25 Antioxidant activities of carnosine, anserine, some free amino acids and their combination [DOI]
- 26 Antifungal properties of Ocimum gratissimum essential oil (ethyl cinnamate chemotype) [DOI]
- 27 Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride [DOI]
- 28 Comparative chemical composition of leaves of some antidiabetic medicinal plants: Azadirachta indica, Vernonia amygdalina and Gongronema latifolium [DOI]
- 29 Antiparkinson drug – Mucuna pruriens shows antioxidant and metal chelating activity [DOI]
- 30 Antioxidant activity, nitric oxide scavenging activity and phenolic contents of Ocimum gratissimum leaf extract [DOI]
- 31 Antioxidant action of Guilingji in the brain of rats with FeCl3-induced epilepsy [DOI]
- 32 Antioxidant Activity of Selected Nigerian Green Leafy Vegetables [DOI]
- 33 In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo [DOI]
- 34 A Study Review of Documented Phytochemistry of Vernonia amygdalina (Family Asteraceae) as the Basis for Pharmacologic Activity of Plant Extract
- 35 Vernonia condensataBaker (Asteraceae): A Promising Source of Antioxidants [DOI]
- 36 Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B.
- 37 HORTICULTURALLY PROMISING INDIGENOUS WILD PLANT SPECIES OF THE NIGERIAN FOREST ZONE [DOI]
- 38 Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic β-Cells of Streptozotocin-Induced Diabetic Rats [DOI]
- 39 Comparative Antioxidant Activities of Extracts of Vernonia amygdalina and Ocimum gratissimum Leaves [DOI]
- 40 The protective role of Gongronema latifolium in acetaminophen induced hepatic toxicity in Wistar rats [DOI]
- 41 Vernonia amygdalina Del: A potential prophylactic anti-diabetic agent in lipid complication [DOI]
- 42 Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture [DOI]
- 43 Protective effect of Ocimum sanctum on lipid peroxidation, nucleic acids and protein against restraint stress in male albino rats.
- 44 Response Pattern of Antioxidants to Lipid Peroxide Concentration in Carbon Tetrachloride-Induced Hepato-Toxicity Is Tightly Logistic in Rabbits [DOI]
- 45 Antioxidant activity of selected Nigerian green leafy vegetables [DOI]
- 46 Gross morphometric reduction of rats' cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract.
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