Natural Compounds Found in the Saliva of the Brazilian Termite Nasutitermes: Innovative and Sustainable Technologies for Dental Applications

Abstract

Brazilian biodiversity provides biological resources with significant potential for dental applications, particularly the secretion (or “slime”) produced by termites of the genus Nasutitermes. This study investigated the bioactive properties of this secretion, traditionally used in ethnomedicinal practices, aiming to explore its integration into dental biomaterials. Through qualitative analysis and methodological triangulation, empirical and laboratory data were systematized, bridging cultural and scientific perspectives. Previous studies identified diterpenes with antimicrobial activity extracted from Nasutitermes macrocephalus, reinforcing the slime’s potential as an antimicrobial and bioadhesive agent in sealants and composite resins. The slime exhibits viscosity and adhesiveness compatible with dental use. However, toxicity testing and evaluation of its interaction with the oral microbiome are still required. Furthermore, its antioxidant and antifungal potentials have been demonstrated in protective formulations against pathogenic biofilms. The ecological relevance, sustainability, and chemical richness of termite slime align with green innovation trends in restorative dentistry, suggesting its application in safe and effective biomaterials. We conclude that Nasutitermes slime represents a promising resource for the development of dental technologies, although clinical trials and standardization are necessary for commercial use.