An Overview on Biochemical Parameters and Organ Injury in COVID-19 Patients

Abstract

The Coronavirus disease (COVID-19) is considered as a respiratory disease which can cause a multi-organ injury like acute cardiac injury, kidney injury, and liver dysfunction. COVID-19 patients had The different of blood biochemical abnormalities where found in covid -19 patients which might indicate multiple organ dysfunction. Hence the aim of the present study is provision of overview on organ injury and changes in biochemical parameters in Covid-19 patients. The common laboratory abnormalities in COVID-19 patients included elevated inflammatory markers like CRP, ferritin, procalcitonin, cytokines and IL-6, IL-2, IL-7 and elevated  prothrombin time and D-dimer. The cardiac injury is shown by increased concentration of CK-MB, LDH, and cTn  and brain natriuretic peptide (BNP). In liver and kidney dysfunction mild or moderate elevation of AST, ALT, total bilirubin, ALP, GGT, hypoalbuminemia, blood urea, creatinine and electrolyte disturbances were seen. Hence reviewing currently available data, the present study can suggest that monitoring of the biochemical parameters may help in prediction of organ damage which further can prevent disease progression early interventions.