Myocarditis Induced by Immunotherapy: A Rare but Fatal Complication
P. M. Mulendele, M. Njie, M. B. Charfo, G. M. Lukifimpa, M. S. Boutar, B. E. Ovaga, M. HABOUB, S. AROUS, M. G. Benouna, A. DRIGHIL, L. Azzouzi, R. HABBAL
Cardiology and Angiology: An International Journal · pp. 201–212 · Published 6 Sep 2023
10.9734/ca/2023/v12i4360Abstract
The emergence of immunotherapy and the gradual expansion of its indications in oncology will require particular vigilance to detect and quickly take care of the potential cardiac toxicities. They have improved prognosis and survival, including patients with kidney, lung or skin cancers (melanoma) and certain lymphomas. The incidence of unwanted cardiac events under immunotherapy is rare, undoubtedly less than 1 % under Ipilimab, Pembrolizumab and Nivolumab. Cardiac toxicity can be induced by many drugs but this time we focused on myocarditis induced by immuno-modulators, which is a rare but very fatal complication and has 2 main parts: an illustration of a clinical case and a review of the literature comprising generality, pathophysiology, clinical manifestations, diagnostic strategy and therapeutic management based on the guidelines of the European Society of cardiology on cardio-oncology recently published in 2022. Corticosteroids are drugs effective in the treatment of cardiac toxicity induced by immunotherapy.
References (18)
- 1 Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [DOI]
- 2 Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases [DOI]
- 3 Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [DOI]
- 4 Fulminant Myocarditis with Combination Immune Checkpoint Blockade [DOI]
- 5 Myocarditis in Patients Treated With Immune Checkpoint Inhibitors [DOI]
- 6 Immune-checkpoint inhibitors: long-term implications of toxicity [DOI]
- 7 Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy [DOI]
- 8 Clinical Features, Management, and Outcomes of Immune Checkpoint Inhibitor–Related Cardiotoxicity [DOI]
- 9 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS) [DOI]
- 10 Abatacept for Severe Immune Checkpoint Inhibitor–Associated Myocarditis [DOI]
- 11 Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma [DOI]
- 12 Cardiovascular immunotoxicities associated with immune checkpoint inhibitors: a safety meta-analysis [DOI]
- 13 Cardiovascular Toxicities Associated with Cancer Immunotherapies [DOI]
- 14 Acute Lymphocytic Myocarditis With Anti-PD-1 Antibody Nivolumab [DOI]
- 15 MYOCARDITIS IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS [DOI]
- 16 Coronary Toxicities of Anti-PD-1 and Anti-PD-L1 Immunotherapies: a Case Report and Review of the Literature and International Registries [DOI]
- 17 Churg–Strauss Syndrome Presenting with Acute Myocarditis and Cardiogenic Shock [DOI]
- 18 The era of bioengineering: how will this affect the next generation of cancer immunotherapy? [DOI]
Cited by 2
Rachida Habbal, Saadia Ouarrak, Hind Dehbi · Cardiology and Angiology: An International Journal · 2024
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Related research
- Sudden Cardiac Death — shares topic coverage
- Myocarditis and Autoimmune Disease Development Following Bariatric Surgery: A Possible Nutritional Deficiency Link — shares topic coverage
- Myocarditis during SARS-CoV-2 Infection: A Series of 15 Cases — shares topic coverage
- Death Due to Low Voltage Electric Shock Induced Myocarditis — shares topic coverage
- Serial Electrocardiographic Changes in a Young Female with Acute Myocarditis — shares topic coverage
Article metrics
Real usage data collected on this platform.
76
Page views
0
PDF downloads
32
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.