Evaluating the Antibacterial Activity of Transition Metal Complexes Derived from 4(4-sulpophenylazo) Pyrogall

Abstract

Background: A new azoic reagent was prepared by reacting the diazonium salt of sulfadiazine with pyrogallol. This reagent's chelated complexes with the metal ions Ag(I), Ni(II), and Co(II) were made. Methods: Thin-layer chromatography (TLC) with a toluene-methanol (2:3) solvent solution was used to confirm the dye's purity. In an open capillary tube, the pure dye's melting point was determined to be between 165 and 167 °C. Gram-negative bacteria were used to investigate and assess the compounds' antibacterial properties. Results: The results demonstrated the potent antibacterial activity of some of these compounds. Using the agar diffusion technique, the biological effect of this ligand and its metal complexes on the growth of two bacterial species was investigated as antibacterial agents against Salmonella and Klebsiella pneumoniae, which cause a variety of common diseases. We found that this ligand and its metal complexes differed in their biological activity in inhibiting bacterial growth. Conclusion: According to the study, the resulting ligand and metal complexes have biological activity and could potentially be used as pharmaceuticals in the medical field, comparable to drugs such as ampicillin.