Moringa oleifera Enriched Diet Ammeliorates the Toxic Effects of Palm Wine and Local Gin (Ogogoro) on Some Biochemical Parameters in Albino Rats

Abstract

The effect of Moringa oleifera enriched diet on the toxic effects of palm wine and local gin on liver enzymes, lipid profile and electrolytes in albino rats was determined in this research. Methodology: Thirty female albino wistar rats, aged 8 to10 weeks, weighing between 170 and 200 g were used for the study. They were divided into six groups of five rats each. Group 1 served as the control group (given normal diet),  group 2 rats were given Moringa oleifera enriched diet only, group 3 rats were given 10 ml/kg bwt of palm wine only and fed a normal diet, group 4 rats were given 0.03 ml/kg bwt of local gin and fed a normal diet, group 5 rats were given 10 ml/kg bwt palm wine with Moringa oleifera enriched diet and group 6 rats were given 0.03 ml/kg bwt of local gin with Moringa oleifera  enriched diet. Palm wine and local gin were administered to the rats daily using an oral cannula for 30 days. On the 31st day, the rats were sacrificed and blood was collected through cardiac puncture for the determination of some liver enzymes, lipid profile and electrolytes. Results: The results of this study showed that Moringa oleifera enriched diet significantly decreased (p<0.05) the activities of alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase, and significantly increased (p<0.05) the levels of total protein and albumin when compared with the control rats. Also, Moringa oleifera enriched diet caused significant decrease (p<0.05) in the levels of total cholesterol, triglycerides, low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol; with significant increase (p<0.05) in high density lipoprotein-cholesterol when compared to control rats. Treatment with the extract significantly lowered (p<0.05) the levels of urea and creatinine in Groups 3, 4 and 5 rats compared with Group 2 rats. Furthermore, the significant reduction (p<0.05) in the levels of sodium, potassium, chloride and bicarbonate was reversed by, treatment with M. oleifera enriched diet. Conclusion: The results suggest that the Moringa oleifera enriched diet could possibly ameliorates the toxic effects of palm wine and local gin on some biochemical parameters in rats.