Antimicrobial Resistance Patterns of Bacterial Isolates from Tertiary Care Hospital of North India

Abstract

Antimicrobial resistance is one of the serious health threats in the world and death due to it is projected to reach up to 10 million every year by 2050. In India, the government implemented a National Action Plan on Antimicrobial Resistance (NAP-AMR) intending to develop a laboratory-based AMR surveillance system, guidelines and practices to promote the awareness of the rational use of antibiotics in healthcare communities. In this plane, only five major hospitals are included which is not sufficient to provide the actual status of AMR. The present study focused on the AMR patterns analysis for bacteria isolated from the different health units in SSB heart and multispecialty hospital, Faridabad, Haryana. Clinically relevant samples such as pus & Body fluid, respiratory, urine and blood samples from the suspected patients were screened over a period of 5 months (February to June 2021) and AMR pattern analysis was carried out by using the disc diffusion method (Kirby–Bauer test) and interpretation was made as per the guidelines of recent Clinical and Laboratory Standards Institute. The study revealed that E. coli was the most dominated resistant bacteria. Moreover, aminoglycosides showed 55% resistance against maximum bacterial isolates from respiratory samples while fosfomycin had higher sensitivity i.e. 85% against pathogens from urine samples. The present study concluded that regular susceptibility testing should be conducted with a defined interval to detect the current trend of resistance which helps clinicians in the effective infectious disease management and leads to reducing the burden of AMR.