Skip to content
Research Article Open access CC BY 4.0

Measurement of Choroidal Thickness in Patients of Pseudoexfoliation Syndrome Using Spectral Domain Optical Coherence Tomography

Shah Nawaz, Ejaz Akbar, Tariq Querishi, Asima Afzal

Ophthalmology Research: An International Journal · pp. 1–7 · Published 19 Jan 2016

10.9734/OR/2016/23869

Abstract

Introduction: Pseudoexfoliation (PEX) is a disorder characterized by the progressive accumulation of fibrillary extracellular deposits in several ocular tissues including the iris, anterior chamber angle, lens capsule and zonules. Pseudoexfoliation (PEX) syndrome is known to be associated with both ocular and choroidal blood flow changes. However there are only few studies regarding the Choroidal Thickness (CT) changes in PEX. Aim: To evaluate the choroidal thickness in eyes with pseudoexfoliation syndrome using optical coherence tomography and to compare them with healthy controls. Materials and Methods: Macular Choroidal thickness 70 patients of pseudoexfoliation syndrome and 70 control subjects were compared in this prospective study using Cirrhus Spectral Domain OCT (Carl Zeiss). The choroidal thickness (CT) is measured perpendicularly (from the outer edge of the hyper reflective retinal pigment epithelium to the inner sclera) at the fovea, and 1.5 mm temporal, 3.0 mm temporal, 1.5 mm nasal, and 3.0 mm nasal to the fovea using SD-OCT. Complete ocular and physical examination was also done in all subjects. Results: The mean subfoveal CT was statistically significant thinner in PEX group as compared to healthy controls (245.48±36.42 μm vs. 312.43±30.21 μm, p value=0.03 respectively). The mean CT 1.5mm and 3mm nasal of fovea was also statistically significant thinner in PEX group as compared to healthy controls (205.32±26.89 μm vs. 285.36±28.01μm, p value=0.02 and 145.28±38.92 μm vs. 198.56±32.21 μm, p value=0.04 respectively). The mean CT 1.5 mm and 3 mm temporal of fovea was also thinner in PEX group as compared to healthy controls, however results did not reach any statistical significance. Conclusion: PEX patients have thinner choroids as compared to clinically unaffected healthy individuals.  

Pseudoexfoliation syndrome optical coherence tomography choroidal thickness

References (26)

  1. 1 Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography [DOI]
  2. 2 A Pilot Study of Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes [DOI]
  3. 3 ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY OF THE CHOROID IN CENTRAL SEROUS CHORIORETINOPATHY [DOI]
  4. 4 Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Highly Myopic Eyes [DOI]
  5. 5 Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease [DOI]
  6. 6 Pseudoexfoliation syndrome for the comprehensive ophthalmologist Intraocular and systemic manifestationsHistorical image [DOI]
  7. 7 Subfoveal Choroidal Thickness after Treatment of Central Serous Chorioretinopathy [DOI]
  8. 8 Ocular and Systemic Pseudoexfoliation Syndrome [DOI]
  9. 9 Exfoliation Syndrome???The Most Common Identifiable Cause of Open-Angle Glaucoma [DOI]
  10. 10 Pseudoexfoliative Fibrillopathy in Visceral Organs of a Patient With Pseudoexfoliation Syndrome [DOI]
  11. 11 SUBFOVEAL CHOROIDAL THICKNESS AFTER TREATMENT OF VOGT–KOYANAGI–HARADA DISEASE [DOI]
  12. 12 CHOROIDAL EVALUATION USING ENHANCED DEPTH IMAGING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN VOGT–KOYANAGI–HARADA DISEASE [DOI]
  13. 13 THE EFFECTS OF SILDENAFIL CITRATE ON CHOROIDAL THICKNESS AS DETERMINED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY [DOI]
  14. 14 Relationship Between Choroidal Thickness and Choroidal Circulation in Healthy Young Subjects [DOI]
  15. 15 Measurement of choroidal perfusion and thickness following systemic sildenafil (Viagra®) [DOI]
  16. 16 Ocular hemodynamics in pseudoexfoliation syndrome and pseudoexfoliation glaucoma [DOI]
  17. 17 Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome.
  18. 18 Decreased choroidal thickness in eyes with secondary angle closure glaucoma. An aetiological factor for deep retinal changes in glaucoma? [DOI]
  19. 19 Generalized Transluminance of the Iris and the Frequency of the Pseudoexfoliation Syndrome in the Eyes of Transient Ischemic Attack Patients [DOI]
  20. 20 Twelve hour reproducibility of choroidal blood flow parameters in healthy subjects [DOI]
  21. 21 Pseudoexfoliation syndrome in eyes with ischemic central retinal vein occlusion [DOI]
  22. 22 Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy [DOI]
  23. 23 Measurement of Subfoveal Choroidal Thickness in Pseudoexfoliation Syndrome Using Enhanced Depth Imaging Optical Coherence Tomography [DOI]
  24. 24 Pseudoexfoliation: Epidemiology, Clinical and Scanning Electron Microscopic Study [DOI]
  25. 25 Association Between Risk Factors and Glaucomatous Damage in Untreated Primary Open-angle Glaucoma [DOI]
  26. 26 Early changes in iris blood vessels in exfoliation syndrome [DOI]

Cited by 1

Subfoveal choroidal thickness changes in patients with pseudoexfoliation syndrome (PEX) compared to healthy controls: a systematic review and meta-analysis.

Dimitrios Kazantzis, Genovefa Machairoudia, P. Theodossiadis · Photodiagnosis and Photodynamic Therapy · 2024

Related research

Article metrics

Real usage data collected on this platform.

68

Page views

0

PDF downloads

31

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.