Regioselectivity in the Multicomponent Reaction of 5-aminopyrazoles, Meldrum’s Acid and Triethyl Orthoformate
Afaf M. Abdel Hameed, Ahmed Moukhtar Nour-Eldin, Michael Magdy Ibrahim, Kamal Usef Sadek
Chemical Science International Journal · pp. 1–5 · Published 29 Jun 2015
10.9734/ACSJ/2015/18903Abstract
A regioselective multicomponent synthesis of pyrazolo[1,5-a]pyrimdines-7(4H)-ones 5 is reported. The reaction proceeded regioselectively via initial Michael addition of exocyclic amino function to the intermediately formed 5-ethoxymethylene Meldrum’s acid followed by a ring opening of Meldrum’s acid and subsequent ring closure with the ring nitrogen. The regioselectivity of the reaction was confirmed by the isolation and characterization of the Michael adduct.
Cited by 2
Elina Marinho · Reactions · 2023
Rayees Ahmad Naikoo, Rupesh Kumar, Vipan Kumar · Current Organic Chemistry · 2022
Related research
- Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory — shares topic coverage
- Mpro-SARS-CoV-2 Inhibitors and Various Chemical Reactivity of 1-Bromo- and 1-Chloro-4-vinylbenzene in [3 + 2] Cycloaddition Reactions — shares topic coverage
- Application of β-Phosphorylated Nitroethenes in [3+2] Cycloaddition Reactions Involving Benzonitrile N-Oxide in the Light of a DFT Computational Study — shares topic coverage
- The Role of the Catalyst on the Reactivity and Mechanism in the Diels–Alder Cycloaddition Step of the Povarov Reaction for the Synthesis of a Biological Active Quinoline Derivative: Experimental and Theoretical Investigations — shares topic coverage
- Development of Efficient and Selective Processes for the Synthesis of Commercially Important Chlorinated Phenols — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.