Solution for Dead Space Problem in Ranibizumab Syringe System
Sinan Bilgin, Ozcan Kayikcioglu, Basak Can, Fatma Taneli
Ophthalmology Research: An International Journal · pp. 40–42 · Published 29 Oct 2014
10.9734/OR/2015/13310Abstract
Intravitreal injection of drugs that inhibit the actions of vascular endothelial growth factor bring high economic burden for the health systems. We evaluated the amount of drug volume retained in two different types of syringes with billed and non - billed rubber stopper. Difference between two syringe types is 0.037 g. This indicates a significant amount of volume loss due to dead space between syringe and needle. Consequently, a simple change of design of rubber stopper of the plunger as billed form may reduce significant amount of drug loss due to dead space volume.
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