Biochemical Indices and Haematological Studies of Ethyl Acetate Extract of Persea americana Leaf in Albino Rats

Abstract

The aim of this present study was to evaluate the effect of ethyl acetate extract of P. americana (avocado) on liver and kidney function, lipid profile as well as haematological parameters in albino rats. A total of 20 albino rats were used for this experiment and they were divided into four groups of 5 (A-D) rats each. Group A served as normal control, group B-D served as experimental groups administered with 100, 200 and 400 mg/kg body weight of ethyl acetate extract of Persea americana leaf per day for 4 weeks respectively. This study was conducted in the Department of Biochemistry, Bayero University, Kano, in the month of May, 2018. Liver function test (colorimetric method), kidney indices and lipid profile (spectrophotometry method), and hematological examination (SYSMEX XE-2000) were analysed. Administration of ethyl acetate extract did not produced significant effect on liver and kidney indices in all the treated groups. The extract significantly (P=.05) decrease total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein in all the treated groups. Haematological parameters analysed were not significantly affected in all the treated groups. Thus, ethyl acetate extract of P. americana leaf possesses hypolipidemic potentials and relatively safe for kidney, liver and hematological indices but extremely high doses may not be advisable.