Influence of a Probiotic Milk Drink, Containing Lactobacillus Paracasei Lpc-37, on Immune Function and Gut Microbiota in Elderly Subjects
Sofia D. Forssten, Nuria Salazar, Patricia López, Janne Nikkilä, Arthur C. Ouwehand, Ángeles Patterson, Patricia Ruas-Madiedo, Ana Suarez, Sonia Gonzalez, Miguel Gueimonde
European Journal of Nutrition & Food Safety · pp. 159–172 · Published 29 Dec 2011
Abstract
Immunosenescence and alterations in the intestinal microbiota are associated with aging. Immune functions, as well as the intestinal microbiota, can potentially be modified and improved by probiotics, thus being particularly beneficial to elderly consumers. The ability of Lactobacillus paracasei Lpc-37 to modulate immune markers including phagocytic activity, natural killer (NK) cell activity and cytokine profiles, as well as composition and activity of the intestinal microbiota, in healthy elderly subjects was investigated in a randomised, double-blind, placebo-controlled study. Only very limited effects in the measured blood or faecal immune markers or intestinal microbiota could be detected between the fermented milk drinks with or without probiotics. Thus, no significant immunological or microbial effects of the probiotic fermented milk could be detected in this study population.
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