The Patients Infected with Helicobacter pylori are Susceptible to Idiopathic Chronic Uritcaria

Abstract

Chronic Idiopathic Urticaria (CIU) manifested by weal eruptions of unknown cause lasting for more than six  weeks induced by histamine hyper-secretion  due to immunological and non-immunological factors. Hernando-Harder et al. [1] as many other studies supported the possibility of Helicobacter pyloriautoantibodies induction that may cross react with mast cell receptors or increases sensitivity of skin vessels to histamine. Throughout eight months 73 patients referred to Khartoum Dermatology Hospital and 73 normal matched subjects were enrolled to detect possibility of association between H. pylori and chronic urticaria. The stool tests for H. pylori antigen revealed that 6 patients and 2 normal subjects were infected thus there was no wide discrepancy between the two groups but 46.6% of patients showed GIT symptoms. Eradication regimen received by the six CIU patients for three weeks then symptoms reexamined for one, three, and six weeks intervals. The percentage of failure was seen in 33.30% and no patient completely cured. This indicates that there is no association between H. pylori infection and development of CIU but GIT upsets may raise the possibility of other microbes association.