Jatropha tanjorensis Euphorbiaceae Ethanolic Leaves Extract Reverses Phenylhydrazine Induced Haematological Alterations  in Albino Wistar Rats

E. B. Umoren; I. A. Okon; C. Nyenke; E. Modo; N. Amadi; P. I. Brown

doi:10.9734/ejnfs/2023/v15i51309

Research Article Open access CC BY 4.0

Jatropha tanjorensis Euphorbiaceae Ethanolic Leaves Extract Reverses Phenylhydrazine Induced Haematological Alterations in Albino Wistar Rats

E. B. Umoren, I. A. Okon, C. Nyenke, E. Modo, N. Amadi, P. I. Brown

European Journal of Nutrition & Food Safety · pp. 20–29 · Published 5 May 2023

10.9734/ejnfs/2023/v15i51309

Abstract

Introduction: Phenylhydrazine has been used in many studies to evaluate its modulatory effects in various biochemical parameters in whole blood and red blood cell lysate. Jatropha tanjorensis Euphorbiaceae have high antioxidants properties; its leaves phytochemical analysis shows the presence of flavonoids, tanins, terpenoids, saponis. This study investigated the ameliorative effects of Jatropha tanjorensis Euphorbiaceae on phenylhydrazine induced haematological alterations in albino Wistar rats. Materials and Methods: Wistar rats of both sexes (180-200g) were divided into 4 groups (n=5). Group 1 received rat chow; Group 2 received (200 mg/kg) of J. tanjorensis orally. Group 3 received phenylhydrazine only (10 mg/kg). Group 4 received phenylhydrazine (10 mg/kg) + J. tanjorensis (250 mg/kg). All animals were allowed free access to clean drinking water and normal rat chow ad libitum for 35 days. After which animals were sacrificed and blood samples collected for biochemical analysis. Results: Results obtained showed that phenylhydrazine induced normochromic anemia with significant increase in white blood cell count, and neutrophil counts, eosinophils (insignificant) count with a significant reduction in lymphocyte count. However, J. tanjorensis extract reversed the adverse haematological changes induced by phenylhydrazine. Conclusion: In conclusion, Jatropha tanjorensis Euphorbiaceae demonstrated antioxidant, anti-inflammatory, and anti-thrombotic effects and reversed the haematological alterations brought upon by phenylhydrazine administration.

Anemia anti-inflammatory Jatropha tanjorensis phenylhydrazine Wistar rats

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E. B. Umoren, I. A. Okon, C. Nyenke, E. Modo, N. Amadi, P. I. Brown (2023). Jatropha tanjorensis Euphorbiaceae Ethanolic Leaves Extract Reverses Phenylhydrazine Induced Haematological Alterations in Albino Wistar Rats. European Journal of Nutrition & Food Safety , 20–29. https://doi.org/10.9734/ejnfs/2023/v15i51309

Affiliations

E. B. Umoren — Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
I. A. Okon — Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
C. Nyenke — Department of Medical Laboratory Sciences, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
E. Modo — Department of Biochemistry, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
N. Amadi — Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
P. I. Brown — Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.

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