Production of Monoclonal Antibodies in Transgenic Plants

Abstract

Antibodies are one of specialized immune protein and innovative therapeutic agents that provides effective alternatives to treating various human diseases. The existing fermenter based process of production of great value antibodies that have biomedical importance is costly, tedious and low yield obtained via purification process. So far different plant types such as vegetables, cereals and legume plants were used to produce important therapeutic proteins. Expression of antibody in transgenic plants might be a solution to successfully scale up therapeutic antibodies, and lower the production costs. This is due to cheap production cost of plants and large amount of yield would be obtained. This review aims to high light on the possibility and comparison to efficiently produce antibody in different plant organs. Also the review extends to over view the role of plants as a flexible expression system for antibody production, which we foresee to progress alongside the production platforms to manufacture specialized antibodies using transgenic plants.