Association of Polymorphisms in DAZL Gene with Male Infertility
Omar F Khabour, Akram M Al-Azzam, Almuthana A Alfaouri, Faheem Zayed, May F Sadiq
Journal of Advances in Medicine and Medical Research · pp. 41–48 · Published 8 Dec 2012
10.9734/BJMMR/2013/2009Abstract
Objectives: To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males. Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Results: The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility. Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.
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