Genetic Polymorphisms of MTRRA66G Genes and Susceptibility to Acute Lymphoblastic Leukemia in the Yemeni Population
Radfan Saleh, Hassan Hussein Musa, Gamal Abdul Hamid, Muzamil M. Abdel Hamid
Asian Hematology Research Journal · pp. 171–178 · Published 5 Dec 2022
Abstract
Background: Folic acid metabolism has a major role in DNA methylation and synthesis. Genetic Polymorphisms in folate may disrupt enzyme activities and maybe affect the malignant risk. Methionine synthase reductase <MTRR> are very important enzyme for the folate cycle. Objectives: To study the possible relation between polymorphisms of MTRRA66G genes and susceptibility to acute lymphoblastic leukemia (ALL) in Yemeni patients. Methods: A total of 115 patients with ALL attended oncology centers in Yemen and 140 unrelated healthy individuals as a control group was involved in a case-control study. DNA was extracted from collected EDTA venous blood samples and analyzed by polymerase chain reaction-restriction fragment length polymorphism assay [PCR-RFLP]. Results: The frequency of MTRR 66A-G heterozygous (AG), homozygous (GG) and wild type (AA) in cases was 52.2% (60), 22.6% (26), and 25.2% (29), respectively. Whereas, the frequency of MTRR 66A-G heterozygous (AG), homozygous (GG) and wild type (AA) in controls was 46.4% (65), 27.1% (38), and 26.4% (37), respectively. The difference in frequencies were statistically insignificant (P=0.471, OR = 1.065, 95% confidence interval (CI) 0.606–1.873). Conclusion: Our finding for MTRR A66G polymorphism does not associate with the development of acute lymphoblastic leukemia in Yemeni patients.
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