Investigation on the Protective Effect of Jatropha Tanjorensis on Electrolyte Imbalance in Male Mice Exposed to Dichlorvos

Abstract

Aim: This study aimed at investigating the effect of Jatropha tanjorensis on electrolytes of male mice exposed to Dichorvos. Study Design: The study was a completely randomized design employing relevant statistical tools for analysis and interpretation. Place and Duration of Study: The study was carried out in the Department of Animal and Environmental Biology, Rivers State University. The experiment lasted for 35 days between March and June 2024. Methodology: A total of thirty (30) male mice were assigned to six groups of five rats each. Group A (Control). Group B was given 5mg/kg/bw/day of Dichlorvos only. Group C was given 250 mg/kg/bw/day of fresh Jatropha tanjorensis.  Group D was given 250 mg/kg/bw/day of dried Jatropha tanjorensis. Group E was given 5mg/kg/bw/day and 250 mg/kg/bw/day of fresh Jatropha tanjorensis. Group F was given 5mg/kg/bw/day and 250 mg/kg/bw/day of dried Jatropha tanjorensis. After 35 days of the experimental study, blood was collected through ocular puncture and analysis of Potassium, Sodium, Chloride, Bicarbonate and Calcium were done using an electrolyte analyzer, Humlyte plus 5, Germany. Data were analyzed using Microsoft excel 365. Result: Showed a significant elevation of all selected electrolytes in group B and E compared to other groups.  Coadministration of fresh Jatropha tanjorensis (group E) appeared not to have any significant ameliorative effect on production of electrolytes since all the electrolytes assessed increased in group B and E.   However, dried Jatropha tanjorensis showed an ameliorative effect against the toxic effect of DDVP on electrolytes in animals exposed to it. Further research is needed establish the efficacy of J. tanjorensis in human subjects while exposure to insecticides should be regulated.