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Research Article Open access CC BY 4.0

Interleukin 10 Gene Polymorphisms and Susceptibility to Nephropathy in Egyptian Diabetic Patients

Mohammad Sayyed Bakheet

International Journal of Biochemistry Research & Review · pp. 1–11 · Published 6 Jul 2017

10.9734/IJBCRR/2017/34735

Abstract

Background: Type 2 diabetes mellitus (T2DM) is recognized as one of the most common causes of end-stage renal disease. In T2DM patients, a certain cytokine genotype is associated with an increased susceptibility to diabetic nephropathy. Aim: In this study we clarify the relation between IL-10 gene polymorphisms at position (-592 A/C) and its plasma levels in T2D Egyptian patients with and without nephropathy. Methods: 80 subjects were enrolled in this study, 30 diabetic patients without nephropathy, 30 DN patients and 20 healthy control subjects. For all subjects, kidney function tests, FBG, HbA1c, estimation of micro-albuminuria, plasma IL-10 level and IL-10 gene polymorphism were done. Results and Conclusions: Diabetic patients with and without nephropathy exhibited significantly higher FBG, HbA1c than healthy subjects. Creatinine levels were increased in DN patients compared to both diabetic without nephropathy and healthy subjects. There is significant increase in micro-albuminuria levels in DN patients compared to diabetic without nephropathy and healthy control subjects. There is significant increase in IL-10 levels in DN patients compared to diabetic without nephropathy and healthy control subjects. The IL-10-(592) CC genotype associated with an increased risk of type 2 DM and the C allele was significantly associated with an increased risk of type 2 DM, there are no significant differences between the two T2D patient groups as regard IL-10 gene polymorphism.     

IL-10 DM gene polymorphisms micro-albuminuria Egyptian patients kidney function nephropathy

References (20)

  1. 1 Genetic influence on cytokine production and fatal meningococcal disease [DOI]
  2. 2 Variants of the Interleukin-10 Promoter Gene Are Associated With Obesity and Insulin Resistance but Not Type 2 Diabetes in Caucasian Italian Subjects [DOI]
  3. 3 The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome [DOI]
  4. 4 TGF-β enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice [DOI]
  5. 5 Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy [DOI]
  6. 6 Role of IL-10 in the progression of kidney disease [DOI]
  7. 7 High levels of circulating interleukin-10 in diabetic nephropathy patients.
  8. 8 Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran [DOI]
  9. 9 The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals.
  10. 10 Interleukin‐10–592C/A, –819C/T and –1082A/G promoter variants affect the susceptibility to nephropathy in Tunisian type 2 diabetes (T2DM) patients [DOI]
  11. 11 In situ upregulation of IL-10 reflects the activity of human glomerulonephritides [DOI]
  12. 12 The role of inflammation as a pathogenic factor in the development of renal disease in diabetes [DOI]
  13. 13 Association of Interleukin-10 A-592C and T-819C Polymorphisms with Type 2 Diabetes Mellitus [DOI]
  14. 14 Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population [DOI]
  15. 15 An Interleukin-10 Gene Promoter Polymorphism (−592A/C) Associated with Type 2 Diabetes: A North Indian Study [DOI]
  16. 16 IL-10 genotype predicts serum levels of adhesion molecules, inflammation and atherosclerosis in hemodialysis patients [DOI]
  17. 17 The frequency of Th2 type cells increases with time on peritoneal dialysis in patients with diabetic nephropathy.
  18. 18 Pharmacologic Modulators of Nitric Oxide Exacerbate Tubulointerstitial Inflammation in Proteinuric Rats [DOI]
  19. 19 Haplotype-tagging interleukin-10 promoter polymorphism is associated with reduced risk of retinal artery occlusion.
  20. 20 Relationship of Serum Interleukin-10 Level and Its Gene Promoter 592 Polymorphism to Type 2 Diabetes Mellitus

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