Influence of Gut Resistome on Humans with Autism Spectrum Disorder
Dalia Abuljadayel, Ahmed Bahieldin, Budur Alotaibi, Wafa M. Aresh, Reem M. Farsi
Journal of Pharmaceutical Research International · pp. 33–45 · Published 8 Apr 2024
10.9734/jpri/2024/v36i47510Abstract
Recent studies have shed light on the connection between the gut resistome and individuals with autism spectrum disorder (ASD). Environmental factors such as premature birth and exposure to drugs in utero can have a significant impact on children with ASD. Microorganisms present in wastewater, hospitals, and animal production wastewaters have been found to contain various antibiotic-resistant genes (ARGs) that encode resistance to a broad spectrum of antibiotics. Environmental variables are currently considered potential etiological agents of this condition, as genetics alone cannot explain its primary origin. Numerous bacteria found in the gut microbiota (GM) have an impact on human health. Furthermore, a microbe impacted by birth mode, lifestyle, and genetics is present in the intestine. To produce different compounds that affect the host, train the host's immunity, modify drug action and metabolism, regulate gut endocrine function, and eliminate toxins, for example, GM is essential to achieving the intended target for treatment application.
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