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Research Article Open access CC BY 4.0

Indigenous Antidiabetic Medicinal Plants Used in Nigeria: A Review

Chika Anna Idaguko, Mayowa Jeremiah Adeniyi

Asian Plant Research Journal · pp. 81–97 · Published 7 Dec 2023

10.9734/aprj/2023/v11i6234

Abstract

Diabetes mellitus is among the most prevalent endocrine disease that causes morbidity and mortality in Nigeria. Traditional medical system has been used for the both prevention and treatment of diabetes mellitus since ages. This paper reviewed the use of 35 Nigerian plants with putative anti-diabetic properties with the help of published literature. As per the International Union for Conservation of Nature (IUCN), status of these  species  include Sterculia tragacantha, Newbouldia laevis, Solanum anomalum, Ficus exasperate, Raffia palm (Raphia hookeri)  Azadirachta indica, Syzygium cumini, Terminalia catapp, Solanum macrocarpon, Petersianthus macrocarpus, Xylopia aethiopica, Costus aferker-gawl, Spondias mombin, Eucalyptus globulus Parkia biglobosa, Persea americana, Anacardium occidentale,  Vernonia amygdalina  as  least concern.  While the status of Hunteria umbellate and Vitex doniana are reported as threatened and Dacryodes edulis and Dennettia tripetala as vulnerable species. However, the status of Annona muricata, Chrysophyllum albidum, Citrus paradisi Macfad, Aloe vera (Aloe barbadensis) are not evaluated. The following species like Phyllanthus amarus, Phyllanthus niruri and Telfairia occidentalis are data deficient. Most of the species belonging to common families like Solanaceae, Anacardiaceae, Euphorbiaceae, Annonaceae and Rutaceae. This review offers relevant information and recent scientific findings on the plants used to treat and manage diabetes in Nigeria. The cellular mechanisms through which these natural agents exert their protective and therapeutic effects on diabetes mellitus may include antioxidative stress, restricting the breakdown of glycogen, pancreatic β-cell regeneration, gluconeogenesis, anti-inflammatory and intracellular signals transduction pathways. This study concludes that indigenous medicinal herbs utilized in Nigeria have the potential to treat diabetes mellitus in Nigeria. Further studies are needed to discover  potential drugs from these indigenous plants.

Diabetes medicinal plant Nigeria traditional hyperglycemia

References (77)

  1. 1 Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition [DOI]
  2. 2 Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 [DOI]
  3. 3 The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety [DOI]
  4. 4 Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management [DOI]
  5. 5 Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors [DOI]
  6. 6 Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review [DOI]
  7. 7 Prevalence and Risk Factors for Diabetes Mellitus in Nigeria: A Systematic Review and Meta-Analysis [DOI]
  8. 8 Environmental Chemicals and Type 2 Diabetes: An Updated Systematic Review of the Epidemiologic Evidence [DOI]
  9. 9 Diabetes in the Africa region: An update [DOI]
  10. 10 Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds [DOI]
  11. 11 The Growing Importance of Neem (Azadirachta indica A. Juss) in Agriculture, Industry, Medicine and Environment: A Review [DOI]
  12. 12 The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review [DOI]
  13. 13 Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants [DOI]
  14. 14 Preliminary Phytochemical Screening and Antibacterial Properties of Crude Stem Bark Extracts and Fractions of Parkia biglobosa (Jacq.) [DOI]
  15. 15 Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes [DOI]
  16. 16 Anti-diabetic effect of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) fruit acetone fraction in a type 2 diabetes model of rats [DOI]
  17. 17 The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies [DOI]
  18. 18 Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats [DOI]
  19. 19 Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocin-induced diabetic rats [DOI]
  20. 20 Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity [DOI]
  21. 21 The Effect of Harvesting on the Composition of Essential Oils from Five Varieties of Ocimum basilicum L. Cultivated in the Island of Kefalonia, Greece [DOI]
  22. 22 Prevalence and risk factors for diabetes mellitus in Nigeria: a systematic review and meta � analysis [DOI]
  23. 23 Solanecio biafrae: An underutilized nutraceutically-important african indigenous vegetable [DOI]
  24. 24 Antioxidant Properties of Selected African Vegetables, Fruits and Mushrooms: A Review [DOI]
  25. 25 Effect of aqueous leaves extract of Costus afer Ker Gawl (Zingiberaceae) on the liver and kidney of male albino Wistar rat [DOI]
  26. 26 Medicinal and Socio-Cultural Importance of Costus Afer (Ker Grawl) in Nigeria [DOI]
  27. 27 Assessment of In vivo antioxidant properties of Dacryodes edulis and Ficus exasperata as anti-malaria plants [DOI]
  28. 28 Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards [DOI]
  29. 29 Raffia palm (Raphia hookeri) wine: Qualitative sugar profile, functional chemistry, and antidiabetic properties [DOI]
  30. 30 Phytochemistry, acute toxicity and blood profile of albino rats treated with fruit extract of Solanum macrocarpon [DOI]
  31. 31 Ameliorative potentials of medicinal plants on the pathophysiological complications of diabetes mellitus: A review [DOI]
  32. 32 The Antidiabetic Activities of the Aqueous Leaf Extract of Phyllanthus Amarus in some Laboratory Animals [DOI]
  33. 33 Anti-diabetic Activity of Aqueous Extracts of Vitex doniana Leaves and Cinchona calisaya Bark in Alloxan–Induced Diabetic Rats [DOI]
  34. 34 Effects of aqueous leaf extract of azadirachta indica on some haematological parameters and blood glucose level in female rats [DOI]
  35. 35 Comparative Effects of Some Medicinal Plants:Anacardium occidentale, Eucalyptus globulus, Psidium guajava,andXylopia aethiopicaExtracts in Alloxan-Induced Diabetic Male Wistar Albino Rats [DOI]
  36. 36 Effect of aqueous leaf extract of Senecio biafrae on hyperglycaemic and serum lipid profile of alloxan-induced diabetic rats
  37. 37 Evaluation of body weight, serum glucose level and oxidative stress parameters of diabetic rats administered phenolic aqueous leaf extract of Vitex doniana [DOI]
  38. 38 Analgesic and antioxidant activities of stem bark extract and fractions of Petersianthus macrocarpus [DOI]
  39. 39 Antihyperglycemic activities of methanolic leaf extract of Anacardium occidentale (Linn.) on the pancreas of streptozotocin-induced diabetic rats [DOI]
  40. 40 ANTI-DIABETIC AND ANTIOXIDANT POTENTIALS OF AQUEOUS EXTRACT OF EUCALYPTUS GLOBULUS IN EXPERIMENTALLY-INDUCED DIABETIC RATS [DOI]
  41. 41 Effects of aqueous leave extract of Ficus exasperata on pathophysiology and histopathogy of alloxan-induced diabetic albino rats [DOI]
  42. 42 Protein Isolate from Parkia biglobosa Seeds Improves Dyslipidaemia and Cardiac Oxidative Stress in Streptozotocin-Induced Diabetic Rats [DOI]
  43. 43 Phytochemical analysis and antifungi activity of aloe vera leaves [DOI]
  44. 44 The anatomy of the medial collateral ligament of the knee and its significance in joint stability [DOI]
  45. 45 Glucose lowering activities of mombintane I and mombintane II isolated from the leaves of Spondias mombin L [DOI]
  46. 46 The Antidiabetic Activities of the Aqueous Leaf Extract of Phyllanthus amarus In Some Laboratory Animals [DOI]
  47. 47 Antidiabetic Activities of the Aqueous Root Bark and Flower Extracts of Terminalia catappa on Streptozotocin - Induced Diabetes in Male Wister Rats [DOI]
  48. 48 Phytochemical constituents and hyperglycemic effect of aqueous and ethanolic extracts of Murraya koenigii in alloxan induced diabetic rats
  49. 49 Chemo-profiling of eucalyptus and study of its hypoglycemic potential [DOI]
  50. 50 Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery [DOI]
  51. 51 Gestational Diabetes Mellitus—Recent Literature Review [DOI]
  52. 52 The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus [DOI]
  53. 53 Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats [DOI]
  54. 54 Antidiabetic and Antihyperlipidemic Effects of Methanolic Extract of Leaves of Spondias mombin in Streptozotocin-Induced Diabetic Rats [DOI]
  55. 55 African Medicinal Plants [DOI]
  56. 56 Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco [DOI]
  57. 57 Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats
  58. 58 Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment [DOI]
  59. 59 Dacryodes edulis (G. Don) H.J. Lam modulates glucose metabolism, cholinergic activities and Nrf2 expression, while suppressing oxidative stress and dyslipidemia in diabetic rats [DOI]
  60. 60 Phytochemical Screening, Mathematical Analysis and Antimicrobial Activity of Methanolic Seed Extract of Hunteria Umbellata [DOI]
  61. 61 In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum [DOI]
  62. 62 Trado-Medical uses, Chemical Constituents and Biological Activities of Newbouldia laevis (Bignoniaceae): A Review [DOI]
  63. 63 ANTIOXIDANT AND ANTIULCER ACTIVITIES OF ETHANOL LEAF EXTRACT AND FRACTIONS OF SOLANUM ANOMALUM [DOI]
  64. 64 Aqueous extract of Solanum macrocarpon Linn leaves abates hyperglycaemia and expression of glucose transporters gene in alloxan-induced diabetic rats [DOI]
  65. 65 Aqueous extract of Azadirachta indica leaves favorably alters the course of streptozotocin-induced diabetes in rats: A comparative prospective cohort study [DOI]
  66. 66 Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa [DOI]
  67. 67 Effect of Hunteria umbellata Methanolic Seed Extracts on Streptozotocin-induced Diabetic Albino Rats [DOI]
  68. 68 Comparative Studies on Phytochemical Screening and in Vitro Antioxidant Activities of Aqueous Extracts of Anacardium Occidentale Leaves and Nuts [DOI]
  69. 69 Comparison of phytochemical constituents of ethanol leaf extracts of Solanum macrocarpon and Vernonia amygdalina [DOI]
  70. 70 Evaluation of the anti-diabetic effect of the methanol leaf extract and fractions of Dennettia tripetala G. Bak (Annonaceae) in alloxan- induced diabetic mice [DOI]
  71. 71 Phytochemistry and antidiabetogenic property of aqueous extract of Azadirachta indica leaf in streptozotocin-induced diabetic rats [DOI]
  72. 72 Effect of Ocimum gratissimum Leaf-extract on Hematological Indices and Lipid Profile of Streptozotocin-induced Diabetic Wistar Rats [DOI]
  73. 73 Evaluation of the anti-diabetic potential of methanol seed extract of Telfairia occidentalis [DOI]
  74. 74 Phytochemical Evaluation and Anti-Diabetic Effects of Ethanolic Leaf Extract of Petersianthus macrocarpus on Streptozotocin-Induced Diabetic Rats [DOI]
  75. 75 Evaluation of the Effects of Citrus paradisi (Rutaceae) Fruit Juice on Electrolyte, Hepatic, Haematological and Histological Derangements in Streptozotocin-Induced Diabetic rats.
  76. 76 Solanum anomalum Leaf Extract and Fractions Attenuate Oxidative Stress and Liver Injuries in Alloxan-Induced Diabetic Rats [DOI]
  77. 77 Antidiabetic Activities of Terminalia Species in Nigeria [DOI]

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