Incidental Solid Pseudopapillary Neoplasm of the Pancreas in a Young Female: Case Report and Literature Review

Abstract

Introduction: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare epithelial tumor with low malignant potential, predominantly affecting young women, and is often discovered incidentally. Presentation of Case: We report the case of a 21-year-old female with no significant medical history who presented with one-month secondary amenorrhea. An abdominal ultrasound revealed an incidental pancreatic mass. Contrast-enhanced computed tomography and magnetic resonance imaging demonstrated a well-circumscribed lesion in the pancreatic body, without vascular invasion or metastatic spread. Endoscopic ultrasound-guided biopsy revealed solid and pseudopapillary architecture, and immunohistochemistry confirmed SPN. After multidisciplinary discussion, the patient underwent central pancreatectomy. Histopathological examination confirmed SPN staged pT2 Nx. The postoperative course was uneventful. Conclusion: SPN should be considered in the differential diagnosis of pancreatic lesions in young women, even when incidentally discovered. In general, complete surgical resection, including parenchyma-sparing procedures such as central pancreatectomy, is associated with excellent long-term outcomes and prognosis in the vast majority of cases.