In-vitro Measurement of Glucose Concentration in Human Blood Plasma Mixed Intralipid Phantom Samples by Using Modulated Ultrasound and Infrared Light
Anuj Srivastava, Md. Koushik Chowdhury, Shiru Sharma Sharma, Neeraj Sharma
Biotechnology Journal International · pp. 1–14 · Published 1 Apr 2016
10.9734/BBJ/2016/24861Abstract
Non-invasive blood glucose measurement is one of most innovative domain in Biomedical Engineering. Multiple methodologies have-been introduced over last few decades to fulfil the clinical requirement for non-invasive glucose measurement in human beings, however, without a successful breakthrough. This research article uses modulated ultrasound with infrared light-based technique to study glucose-induced variations in human blood plasma mixed IntralipidTM phantom samples using infrared light of 940 nm and 40 kHz central frequency based ultrasonic transmitter unit. The test uses blood samples of 30 study subjects during oral glucose tolerance test and fasting, postprandial and random stages based blood glucose tests respectively. The result as obtained from oral glucose tolerance tests and fasting, postprandial and random stages blood glucose tests showed peak amplitude values in Fast Fourier Transform domain varies in corresponding to blood glucose levels in in-vitro samples. The Bland Altman plot, Error Grid and statistical analysis represent the potentiality and feasibility of our technique for non-invasive blood glucose measurement.
References (66)
- 1 STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [DOI]
- 2 An Introduction to Medical Statistics. [DOI]
- 3 Evaluating Clinical Accuracy of Systems for Self-Monitoring of Blood Glucose [DOI]
- 4 Multiphoton microscopy in life sciences [DOI]
- 5 On the acoustic radiation pressure on spheres [DOI]
- 6 Acoustic radiation pressure on a compressible sphere
- 7 A new consensus error grid to evaluate the clinical significance of inaccuracies in the measurement of blood glucose. [DOI]
- 8 Glucose sensors: a review of current and emerging technology [DOI]
- 9 Optical properties of intralipid: A phantom medium for light propagation studies [DOI]
- 10 Non-invasive glucose monitoring technology in diabetes management: A review [DOI]
- 11 Spectroscopic and Clinical Aspects of Noninvasive Glucose Measurements [DOI]
- 12 Separation of lipids from blood utilizing ultrasonic standing waves in microfluidic channels [DOI]
- 13 Evaluating the Accuracy of Continuous Glucose-Monitoring Sensors [DOI]
- 14 Non-Invasive Glucose Measurement Technologies: An Update from 1999 to the Dawn of the New Millennium [DOI]
- 15 First human experiments with a novel non-invasive, non-optical continuous glucose monitoring system [DOI]
- 16 Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues [DOI]
- 17 The Surveillance Error Grid [DOI]
- 18 Technical Aspects of the Parkes Error Grid [DOI]
- 19 Noninvasive Glucose Monitoring [DOI]
- 20 Continuous Subcutaneous Glucose Monitoring in Diabetic Patients [DOI]
- 21 Noninvasive In Vivo Clot Dissolution Without a Thrombolytic Drug [DOI]
- 22 Accuracy of Perceiving Blood Glucose in IDDM [DOI]
- 23 Enhancement of Fibrinolysis With 40-kHz Ultrasound [DOI]
- 24 In Vivo Noninvasive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy [DOI]
- 25 Non-invasive glucose monitoring in patients with diabetes: A novel system based on impedance spectroscopy [DOI]
- 26 Effect of 40-kHz Ultrasound on Acute Thrombotic Ischemia in a Rabbit Femoral Artery Thrombosis Model [DOI]
- 27 Ultrasonic separations in analytical biotechnology [DOI]
- 28 Non-invasive glucose monitoring in patients with Type 1 diabetes: A Multisensor system combining sensors for dielectric and optical characterisation of skin [DOI]
- 29 A Novel Noninvasive Blood Glucose Monitor [DOI]
- 30 Noninvasive Continuous Glucose Monitoring Using Photoacoustic Technology—Results from the First 62 Subjects [DOI]
- 31 Noninvasive Glucose Monitoring: Increasing Accuracy by Combination of Multi-Technology and Multi-Sensors [DOI]
- 32 Low-Frequency Ultrasound (20-40 kHz) as an Adjunctive Therapy for Chronic Wound Healing [DOI]
- 33 Characteristics of a multisensor system for non invasive glucose monitoring with external validation and prospective evaluation [DOI]
- 34 How to Assess and Compare the Accuracy of Continuous Glucose Monitors? [DOI]
- 35 Non-invasive glucose measurement based on selective near infrared absorption; requirements on instrumentation and spectral range [DOI]
- 36 Modelling, verification, and calibration of a photoacoustics based continuous non-invasive blood glucose monitoring system [DOI]
- 37 New technologies for diabetes: a review of the present and the future [DOI]
- 38 Observation of particles manipulated by ultrasound in close proximity to a cone-shaped infrared spectroscopy probe [DOI]
- 39 The influence of blood glucose level upon the transport of light in diabetic and non-diabetic subjects [DOI]
- 40 Blood cell banding in ultrasonic standing wave fields: A physical analysis [DOI]
- 41 Modulation of ultrasound to produce multifrequency radiation force [DOI]
- 42 Joint optical-electrical technique for noninvasive glucose monitoring
- 43 Polarimetric glucose sensing using the Brewster-reflection off the eye lens: theoretical analysis [DOI]
- 44 Noninvasive blood glucose measurement by ultrasound-modulated optical technique [DOI]
- 45 Photoacoustic blood glucose and skin measurement based on optical scattering effect [DOI]
- 46 Design of a portable noninvasive photoacoustic glucose monitoring system integrated laser diode excitation with annular array detection [DOI]
- 47 Experiments with ultrasonic transducers [DOI]
- 48 Wave experiments using low-cost 40 kHz ultrasonic transducers [DOI]
- 49 New optical method for noninvasive blood glucose measurement by optical ultrasonic modulation [DOI]
- 50 Noninvasive Glucose Monitoring: A Novel Approach [DOI]
- 51 Measuring agreement in method comparison studies [DOI]
- 52 Light scattering in lntralipid-10% in the wavelength range of 400–1100 nm [DOI]
- 53 Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises [DOI]
- 54 Non-invasive glucose monitoring: Assessment of technologies and devices according to quantitative criteria [DOI]
- 55 Raman spectroscopy for noninvasive glucose measurements [DOI]
- 56 Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation [DOI]
- 57 Evaluating the Clinical Accuracy of GlucoMen®Day: A Novel Microdialysis-Based Continuous Glucose Monitor [DOI]
- 58 ABC of Diabetes
- 59 Pulsed Photoacoustic Techniques and Glucose Determination in Human Blood and Tissue [DOI]
- 60 The Potential Application of Amplitude Modulated Ultrasound with Infrared Technique for Blood Glucose Level Determination in Non Invasive Manner [DOI]
- 61 Practical Biochemistry for Medical Students [DOI]
- 62 Five days daily sessions of noninvasive blood glucose level predictions based on amplitude modulated ultrasound and infrared technique over a healthy and diabetic subject [DOI]
- 63 Statistical Analysis for Glucose Prediction in Blood Samples by Infrared Spectroscopy [DOI]
- 64 Continuous Noninvasive Glucose Monitoring Technology Based on “Occlusion Spectroscopy” [DOI]
- 65 Requirements for Calibration in Noninvasive Glucose Monitoring by Raman Spectroscopy [DOI]
- 66 ABC of Diabetes Fifth Edition [DOI]
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