Skip to content
Research Article Open access CC BY 3.0

In vitro–In vivo Correlation Studies of Modified Release Solifenacin Tablet Dosage Form

P. Srinivasa Babu, SK. Rihana Parveen, K. B. Chandrasekar, B. R. Challa, Bahlul Zayed Sh. Awen

Journal of Scientific Research and Reports · pp. 1905–1915 · Published 18 Jun 2014

10.9734/JSRR/2014/9951

Abstract

A modified release formulation of Solifenacin tablet, was investigated in rabbit for pharmacokinetic and in vitro–in vivo correlation studies. In vivo study was conducted in New Zealand albino male rabbit plasma and In vitro release studies were conducted in simulated gastric fluid and analyzed by using validated HPLC method. The In vivo–In vitro correlation coefficients obtained from point-to-point analysis were greater than 99% between concentrations at certain time points obtained from release study in simulated gastric fluid at specific RPMs and HPLC analysis of rabbit’s plasma. From the in vitro–in vivo correlation prediction it was evident that the Solifenacin modified release tablet is a good for controlled delivery of Solifenacin.

Solifenacin modified release In vitro – In vivo correlation.

References (19)

  1. 1 Bracketing and Matrixing Designs for Stability Testing of New Drug Substances and Products [DOI]
  2. 2 A comprehensive non‐clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder [DOI]
  3. 3 Clinical Pharmacokinetics and Pharmacodynamics of Solifenacin [DOI]
  4. 4 In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment [DOI]
  5. 5 Highly sensitive and rapid LC–ESI-MS/MS method for the simultaneous quantification of uroselective α1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma [DOI]
  6. 6 Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females [DOI]
  7. 7 A Validated Rapid Stability-Indicating Method for the Determination of Related Substances in Solifenacin Succinate by Ultra-Fast Liquid Chromatography [DOI]
  8. 8 Development and validation of stability-indicating HPLC method for solifenacin succinate: Isolation and identification of major base degradation product [DOI]
  9. 9 Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography [DOI]
  10. 10 Development and Validation of a Specific Stability Indicating High Performance Liquid Chromatographic Methods for Related Compounds and Assay of Solifenacin Succinate [DOI]
  11. 11 Determination of solifenacin in human plasma by liquid chromatography–tandem mass spectrometry [DOI]
  12. 12 Solifenacin succinate for the treatment of overactive bladder [DOI]
  13. 13 Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis ofIn VivoDrug-Receptor Binding [DOI]
  14. 14 Report of the Workshop on In Vitro and In Vivo Testing and Correlation for Oral Controlled/Modified-Release Dosage Forms [DOI]
  15. 15 Solifenacin Demonstrates High Absolute Bioavailability in Healthy Men [DOI]
  16. 16 Open-Label Study of the Safety and Pharmacokinetics of Solifenacin in Subjects With Hepatic Impairment [DOI]
  17. 17 Food does not affect the pharmacokinetics of solifenacin, a new muscarinic receptor antagonist: results of a randomized crossover trial [DOI]
  18. 18 Development and Validation of Stability-Indicating HPTLC Method of Solifenacin Succinate
  19. 19 A SPE-LC-MS/MS Method for the Detection of Low Concentrations of Pharmaceuticals in Industrial Waste Streams [DOI]

Cited by 1

Structural investigation, molecular structure and molecular docking of solifenacin succinate, flavoxate hydrochloride and tolterodine tartrate anti-cholinergic drugs

Ali K. Attia, Gehad G. Mohamed, Heba E. Ahmed · Journal of Thermal Analysis and Calorimetry · 2017

Related research

Article metrics

Real usage data collected on this platform.

40

Page views

0

PDF downloads

18

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.