In Silico Drug Discovery of 4-Hyroxypanduratin A, 6-Gingerol and Luteolin Targeting Nipah Virus
Anurag Verma, Piyush Mittal, Milind S. Pande, Neelanchal Trivedi
Journal of Pharmaceutical Research International · pp. 477–484 · Published 23 Oct 2021
10.9734/jpri/2021/v33i46B32964Abstract
Nipah Virus is a zoo tonic virus and has re-emerged again with more deadliness. NiV has infected many animals and humans worldwide and a huge loss to life has been faced. NiV contains a Fusion protein on its outer membrane which helps in the virus entry into the host cell. This fusion protein is a virulent factor and is a major anti-viral target. Many medicinal plants have been used against viral diseases, current research aims towards the potential of three daily dietary food elements that can be used as an anti-viral agent. In-silico studies are performed with 4-hyroxypanduratin A, 6-gingerol and Luteolin against the NiV-F and binding energies were calculated. It was reported that these phyto-compounds have good negative binding energies and they have the promising potential against Nipah Virus. Further in-vitro research can be performed with these phyto-compounds to design a specific drug against Nipah Virus.
Cited by 2
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Amritha G. Nambiar, Anuj A. Biswas, Ashish K. Agrawal · Drug Repurposing · 2024
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