Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy
Ehab Abou-eladab, Heba Abdal-razzak Abdel-fattah Mahmoud, Hanaa abdel Kader Ibraheem, Ashraf Mahmoud Kamel, Sameh Fawzy Elsonbaty, Faten Shehata
Journal of Advances in Medicine and Medical Research · pp. 1–9 · Published 28 Jun 2016
10.9734/BJMMR/2016/25678Abstract
The present study aimed to examine the histological changes in the smooth muscles of corpus cavernosum and veins of rats as an eventual outcome of the ceaseless use of Sildenafil citrate. The comparison of the histological aftereffects of the veins among the control and experimental groups revealed extended thickness of tunica intima and media, as exhibited by a picture analyzer. The findings indicated that the steady usage of Sildenafil reduced smooth muscles and enabled the growth of collagen fibers in corpus cavernosum of penis and mass of veins.
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