Impact of Serum Vitamin D Levels on the Preterm Rupture of the Membrane in Pregnant Women. A Cross-sectional Study

Abstract

Aim: To assess the association between premature rupture of membrane and maternal blood vitamin D levels. Study Design: A cross-sectional study. Place and Duration: Abbasi Shaheed Hospital, Karachi Medical and Dental College from April 2020 to April 2021. Methodology: Over the duration of one year, a total of 100 patients with vitamin D levels, as well as obstetrical abnormalities and risk factors, were monitored. In 88 pregnant women, vitamin D deficiency was observed. Pregnant women who have a thyroid disorder, such as thyroiditis or Grave's disease, or who had calcium or parathyroid disease in the past, or who need cardiac medication therapy,& diuretic particularly calcium channel blockers were excluded from the study. Results: Vitamin D deficiency was found in 88 pregnant women out of 100. It was more prevalent among housewives (86.36 percent) and multiparous women (68.0 percent). Pregnancy complications were present in 33.0 percent of cases such as preeclampsia, gestational hypertension, and diabetes, and PROM was less prevalent in the deficient group. Conclusion: Our data indicate that pregnant females are at a greater risk of Vitamin D deficiency, and associated pregnancy complications. The correlation between maternal vitamin D levels & preterm rupture of the membrane was not statistically significant.