Skip to content
Research Article Open access CC BY 4.0

Impact of Benzo (a) Pyrene on Thyroid Glands and their Associated Hormones of Male Mice Mus musculus

Anita Singh Purvia, Vinoy Kumar Shrivastava

Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 31–39 · Published 3 Apr 2024

10.9734/ajbgmb/2024/v16i5375

Abstract

Benzo [a] pyrene is the main representative of polycyclic aromatic hydrocarbons, and has been repeatedly found in the air, surface water, soil, and sediments. Human exposure to Benzo [a] pyrene is therefore common. Benzo (a) pyrane (BaP) which is mainly presented in newspaper ink and inhibits the function of the thyroid and other endocrine glands of the human system, due to several disorders that occur in the human body. Healthy mature male mice Mus musculus having weight of 125 ± 5 gm were used for the experiments. The effects of a Benzo (a) pyrene (26 mg/kg body weight/twice in a week) during experimental periods of 60 and 90 days in male mice Mus musculus showed significant difference in body weights compared to control. We assessed the hormonal estimation of thyroid treated with Benzo (a) pyrene by using an appropriate ELISA assay kit and histopathological changes were observed under a light microscope (magnifications 100X) in the thyroid tissue of male mice Mus musculus exposed to BaP after 60 and 90 days. During the study, we observed that in treated mice thyroid hormone concertation was affected the structure of the thyroid follicles was disturbed and epithelial cells were necrotic compared with the control mice which indicates that the BaP may lead to changes in the thyroid morphology as well as secreted hormone concentration in exposed treated male mice.

Benzo (a) pyrane Mus musculus hormonal histopathological thyroid follicles

References (22)

  1. 1 Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. [DOI]
  2. 2 The global distribution of polycyclic aromatic hydrocarbons in recent sediments [DOI]
  3. 3 One Degree of Freedom for Non-Additivity [DOI]
  4. 4 Exposure to polycyclic aromatic hydrocarbons with special focus on cancer [DOI]
  5. 5 Environmental chemicals and thyroid function [DOI]
  6. 6 Fifty years of benzo(a)pyrene [DOI]
  7. 7 Human dietary exposure to polycyclic aromatic hydrocarbons: A review of the scientific literature [DOI]
  8. 8 Antiestrogenicity of β-naphthoflavone and PAHs in cultured rainbow trout hepatocytes: evidence for a role of the arylhydrocarbon receptor [DOI]
  9. 9 Evaluation of impact of PAH on a tropical fish, Oreochromis mossambicus using multiple biomarkers [DOI]
  10. 10 Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment [DOI]
  11. 11 Changes in thyroid peroxidase activity in response to various chemicals [DOI]
  12. 12 Seasonal variation, air-water exchange, and multivariate source apportionment of polycyclic aromatic hydrocarbons in the coastal area of Dalian, China [DOI]
  13. 13 Interspecies differences in susceptibility to perturbation of thyroid homeostasis: a case study with perchlorate [DOI]
  14. 14 Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat [DOI]
  15. 15 Disruption of the rainbow trout reproductive endocrine axis by the polycyclic aromatic hydrocarbon benzo[a]pyrene [DOI]
  16. 16 Renoprotection of Kolaviron against benzo (A) pyrene-induced renal toxicity in rats [DOI]
  17. 17 Impaired sperm quantity and motility in adult rats following gestational and lactational exposure to environmentally relevant levels of PBDE-47: A potential role of thyroid hormones disruption [DOI]
  18. 18 Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway [DOI]
  19. 19 Three-Generation Evaluation of Dietary para-Nonylphenol in CD (Sprague-Dawley) Rats [DOI]
  20. 20 Effects of Benzo (a) Pyrene and 2,2′,4,4′-Tetrabromodiphenyl Ether Exposure on the Thyroid Gland in Rats by Attenuated Total Reflection Fourier-Transform Infrared Spectroscopy [DOI]
  21. 21 Mechanistic profiling of the cAMP-dependent steroidogenic pathway in the H295R endocrine disrupter screening system: New endpoints for toxicity testing [DOI]
  22. 22 Mutation research/fundamental and molecular mechanisms of mutagenesis [DOI]

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

50

Page views

0

PDF downloads

19

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.