Immune Tuberculous Anergy: An Opinion Perspective

Abstract

Immune Anergy (IA) is based upon cellular and molecular mechanisms that are finalized by T and/or B lymphocyte dysfunction. Comparative immune-biology of anergic B cell, anergic T and anergic T-exhausted T cell were summed up. IA appeared as a block in lymphocyte proliferation and cytokine inhibition. I t is   associated with chronic persistent intracellular microbial infection like tuberculosis and leprosy. It is molecular mechanism found valid for prolongation of tissue graft acceptance and for autoimmunity prevention. IA shared an in common immune features with; immune exhaustion, immune resilience and be a part of immune tolerance. The IA concept, paradigm, mechanisms and immune features were elucidated. Biology of anergy and allied concepts were briefed. The objective of the present opinion paper was to   make an at glance insight to   IA and showcase one of our previous works on tuberculous immune anergy. Adult anergic tuberculous patients have been showing decline in adaptive cellular immune function and normal innate cellular immune functions compared to tuberculin positive pulmonary tuberculosis patients.