Nuclease Activity of the DNA Polymerases: An Evasion of Microscopic Reversibility Leading to Fidelity in Excess of Kinetic Control Levels
Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 1–6 · Published 12 Jun 2018
10.9734/ajbgmb/2018/v1i1454Abstract
The exonuclease and endonuclease activities of the DNA polymerases, which extend their proof-reading capabilities and maintain high fidelity in the replication process, apparently conflict with the principle of microscopic reversibility. However, in-depth mechanistic analysis of the reactions leads to fascinating insights into the kinetic and thermodynamic effects controlling the replication of the primary genetic material. Thus, nucleotide addition and excision involve different pathways, although a violation of microscopic reversibility is avoided as the overall reaction does not reach equilibrium. Intriguingly, however, this allows the fidelity levels to exceed those expected from simple kinetic control.
Cited by 0
No indexed citations yet.
Related research
- Isotopic Self - Programming for the Embryonic Cell DNA Methylation Pattern — shares topic coverage
- Improving the Teleportation of Superposition of Entangled Coherent States — shares topic coverage
- Perceived Sustainability and Reliability of Naturopathic Birth Control Methods; A Study in Ningo-Prampram, Ghana — shares topic coverage
- What Principle Governs the Chemical Dynamic/Kinetic Process (3)? — shares topic coverage
- Aspects of Nucleic Acid Structure and Function — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.