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Research Article Open access CC BY 4.0

Unusual Coexistence of Castleman's Disease and Pityriasis Lichenoides in a Child

Narjess Er-rachdy, Ouissal Essadeq, Taha Aaboudech, Kaoutar Znati, Laila Benzekri, Nadia Ismaili

Asian Journal of Pediatric Research · pp. 15–19 · Published 15 Jul 2025

10.9734/ajpr/2025/v15i7462

Abstract

Castleman disease is a rare lymphoproliferative disorder, particularly in children. Its association with pityriasis lichenoides has not been previously reported. This report presents a 5-year-old girl born to consanguineous parents, who developed recurrent necrotic and bullous skin lesions diagnosed as chronic pityriasis lichenoides (CD8+). One year later, she developed bilateral cervical lymphadenopathy, and imaging revealed multiple necrotic nodes. A lymph node biopsy confirmed hyaline-vascular Castleman disease. This case suggests a potential immunological link between chronic pityriasis lichenoides and Castleman disease. The patient is scheduled for surgical excision of the lymph node mass and will undergo continued dermatologic follow-up. This is the first pediatric case reporting this rare coexistence, highlighting the need for systemic evaluation in chronic dermatoses with lymphadenopathy.

Castleman disease pityriasis lichenoides CD8 hyaline-vascular child lymphadenopathy

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