Skip to content
Research Article Open access CC BY 4.0

Histological Changes in Testis of Adult Wistar Albino Rats - Nicotine-Induced Testicular Damages and the Protective Effects of Methanolic Extract of Sphaeranthus Amaranthoides

S. Kanimozhi, Govindarajan Sumathy, Elumalai Prithiviraj

Journal of Pharmaceutical Research International · pp. 511–516 · Published 29 Dec 2021

10.9734/jpri/2021/v33i63B36038

Abstract

Nicotine which is the most dynamic substance present in tobacco is the vital cause of damaging the tissues and oxidative stress that in turn is the principal cause of numerous diseases. The succession and severity of nicotine toxicity which may be adjourned by the natural antioxidants may cause serious health, knock. We have scrutinized the consequences of methanolic extract of Sphaeranthus amaranthoides (SAE) on nicotine-induced reproductive toxicity, oxidative damage, and hepatotoxicity in adult Wistar male albino rats. In four groups 24 rats were contingently split up. Control,  Nicotine N (0.4 mg/kg. i.p) methanolic extract of Sphaeranthus amaranthoides (SAE) and (N+ SAE) group. In order to compute the levels of testosterone and to measure the hematological and oxidative stress parameters, blood samples were collected after 48 days. The reproductive organs were weighed and taken for semen analysis and histopathology study.  We could see decrease in the levels of testosterone, weights of reproductive organs, and even in the morphological features of sperms due to reproductive toxicity of Nicotine. On histological examination, testis showed atrophy, degenerative alterations of spermatogenesis in numerous seminiferous tubules together with increased interstitial spaces and a decrease in the number of Leydig cells. SAE played a defensive role against nicotine which persuaded the reproductive effects by enhancing the spermatogenesis, semen quality, and testicular histological damage.

Nicotine rats reproductive toxicity tobacco male infertility and spermatogenesis sphaeranthus amaranthoides antioxidants

References (20)

  1. 1 Guidelines on nicotine dose selection for in vivo research [DOI]
  2. 2 A review on bio-synthesized zinc oxide nanoparticles using plant extracts as reductants and stabilizing agents [DOI]
  3. 3 Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke [DOI]
  4. 4 Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: Association with cigarette smoking [DOI]
  5. 5 Cigarette smoking and the risk of male factor subfertility: minor association between cotinine in seminal plasma and semen morphology [DOI]
  6. 6 Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract [DOI]
  7. 7 Effect of cigarette smoke on spermatogenesis in rats.
  8. 8 Effect of Smoking on Concentration, Motility and Zona-Free Hamster Test on Human Sperm [DOI]
  9. 9 Nicotine-induced damages in testicular tissue of rats; evidences for bcl-2, p53 and caspase-3 expression. [DOI]
  10. 10 Nicotine intake by snuff users. [DOI]
  11. 11 Testicular changes due to graded doses of nicotine in albino mice.
  12. 12 Morphometrical, Histopathological, and Cytogenetical Ameliorating Effects of Green Tea Extract on Nicotine Toxicity of the Testis of Rats [DOI]
  13. 13 The Role of Coconut Water on Nicotine-Induced Reproductive Dysfunction in Experimental Male Rat Model [DOI]
  14. 14 Phytochemical and GC–MS analysis of bioactive compounds of Sphaeranthus amaranthoides Burm [DOI]
  15. 15 Nicotine and cotinine inhibit steroidogenesis in mouse leydig cells [DOI]
  16. 16 Sperm abnormality toxicity due to cyclosporine A and the ameliorative effect of royal jelly in male rats [DOI]
  17. 17 Royal‐jelly‐based apitherapy can attenuate damages to male reproductive parameter following nicotine administration [DOI]
  18. 18 The bioequivalent and effect of nicotine formulation gum on smoking cessation.
  19. 19 Pharmacological Study of a Siddha Holistic Herb Sivakaranthai - Sphaeranthus Amaranthoides Burm for Analgesic and Anti-Inflammatory activities.
  20. 20 Protective Effects of Plants Against Nicotine Induced Reproductive Toxicity in Male Animal Models: A Literature Review [DOI]

Cited by 1

Efficacy Of Methanolic Extract Of Sphaeranthus amaranthoides Burm Against Hormonal Changes Induced By Nicotine In Male Adult Wistar Albino Rats

S.Kanimozhi, R.Sathish Adithya, G.Sumathy · Cardiometry · 2023

Related research

Article metrics

Real usage data collected on this platform.

3

Page views

0

PDF downloads

0

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.