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Histological and Histochemical Evaluation of Anticadmium Toxicity Effects of Moringa oleifera Seed Oil and Anacardium occidentale Nut Oil in the Hippocampus of Juvenile Male Wistar Rats

O. D. Omotoso, J. O. Owolabi, Y. J. Samanja, B. J. Dare, E. A. Ashamu, S. A. Adelakun

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–13 · Published 24 Oct 2015

10.9734/JAMPS/2016/16035

Abstract

The hippocampus is a part of the brain involved in memory formation, organization and storage; being a limbic system structure that is particularly important in forming new memories and connecting emotions and senses, such as smell and sound, to memories. Cadmium on the other hand is a metallic poison that affects the brain tissues as a whole, producing seriously deleterious effects. Antioxidants could ameliorate the negative effects of toxic substances on body tissues. Since Moringa oleifera seed and Anacardium occidentale nut oils are natural edible oils that are greatly rich in antioxidants and medicinal phytochemicals, it is important to observe their potentials in helping the body to combat the effects of cadmium toxicity particularly on the hippocampus. Thirty five juvenile male Wistar rats were grouped into seven: A, B, C, D, E, F and G. Group A served as the control and the animals were fed ad libitum; other groups had each animal administered 2.5 mg/kg body weight of 3CdSO4.8H2O to induce cadmium toxicity prior to treatment with the agents employed. Each Group B rat was left untreated to observe the effects and nature of cadmium toxicity; each Group C animal received 5 mg/kg body weight Vitamin C dissolved in 0.9% NaCl solution orally. Group D animals were given a daily dosage of 6 mg/kg body weight Vitamin E dissolved in olive oil each. Group E rats were treated with 4 mg/kg body weight Moringa oleifera seed oil each; Group F rats were treated with 4 mg/kg body weight Anacardium occidentale nut oil and group G rats were treated with 2 mg/kg body weight Moringa oleifera seed oil plus 2 mg/kg body weight Anacardium occidentale nut oil. Cadmium intoxication has observable deleterious effects on brain tissues. All agents used produced positive anti-cadmium effects, however to varying degrees. The natural oils were more potent than the selected regularly used antioxidants.  

Hippocampus cadmium toxicity antioxidants Moringa oleifera Anacardium occidentale

References (15)

  1. 1 Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. [DOI]
  2. 2 Antioxidant Properties of Various Solvent Extracts of Total Phenolic Constituents from Three Different Agroclimatic Origins of Drumstick Tree ( Moringa oleifera Lam.) Leaves [DOI]
  3. 3 The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves [DOI]
  4. 4 Rewarded Outcomes Enhance Reactivation of Experience in the Hippocampus [DOI]
  5. 5 Histology of the Central Nervous System [DOI]
  6. 6 Antioxidant activity of anacardic acids [DOI]
  7. 7 Physico-chemical and Antioxidant Properties of Moringa oleifera Seed Oil [DOI]
  8. 8 Extraction and identification of natural antioxidant from the seeds of the Moringa oleifera tree variety of Malawi [DOI]
  9. 9 Neurotoxic effects of cadmium in young rats*1 [DOI]
  10. 10 Oxidative stress-mediated neurotoxicity of cadmium [DOI]
  11. 11 Influence of ethanol on cadmium accumulation and its impact on lipid peroxidation and membrane bound functional enzymes (Na+, K+-ATPASE and acetylcholinesterase) in various regions of adult rat brain [DOI]
  12. 12 Neural dynamics of the cognitive map in the hippocampus [DOI]
  13. 13 Increase of striatal dopamine release by cadmium in nursing rats and its prevention by dexamethasone-induced metallothionein [DOI]
  14. 14 Antioxidant activity of various extracts of leaves of Anacardium occidentale (cashew).
  15. 15 Hippocampus minor and man's place in nature: A case study in the social construction of neuroanatomy [DOI]

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