Sticky Bone: Stability Meets Biology in Periodontal Regeneration- A Narrative Review

Abstract

Periodontal regeneration is a therapeutic procedure aimed at re-establishing the lost tooth-supporting tissues—alveolar bone, periodontal ligament, and cementum—by promoting the formation of new, functional attachment. It is biologically driven, cell-selective phenomenon in which the nature of healing is determined by the specific cell population that repopulates the root surface. Among these, cells derived from the periodontal ligament possess the distinctive capability to form new cementum, alveolar bone, and functionally oriented Sharpey’s fiber’s, thereby enabling true regenerative attachment. Various methods include guided tissue regeneration, bone graft, tissue engineering and enamel matrix derivative. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that has gained growing recognition in recent years for its applications in regenerative procedures. Sticky bone is created by combining autologous platelet concentrates with particulate bone graft materials, thereby integrating persistent growth factor release with structural scaffold support.