Green Approaches of Flavonoids in Cancer: Chemistry, Applications, Management, Healthcare and Future Perspectives

Abstract

In epidemiologic research, a cancer preventive benefit from plant-derived meals has been discovered with unusual consistency. However, identifying individual components responsible for this effect has been difficult. The polyphenols phytochemicals have been found to have biological activity, and they may work together to prevent cancer. Cancer is a significant public health concern in both developed and developing countries. Celery, chamomile, Ginkgo biloba, mint, red paper plants synthesized anticancer agents like taxol, irinotecan, camptothecin, topotecan, and vinblastine, vincristine, etoposide being used in clinical trials. In addition, Flavopiridol, roscovitine, combretastatin A-4, betulinic acid, and silvestrol are promising anticancer compounds. Flavonoids in vegetables, fruits, roots, and stems have demonstrated a wide range of anticancer properties, including modulating ROS, scavenging enzyme activities, participating in cell cycle arrest inducing apoptosis autophagy, and suppressing growth of tumour cell and invasiveness. This review highlighted flavonoids, cancer cell mechanism of action, applications in tumour management, and future perspectives. This review may play a significant role for industrialists and scientists working in this field.